Relationship between <i>TAP</i>2 gene polymorphism and susceptibility to pulmonary tuberculosis based on a case-control family study

LUO Jia-ze; HU Kuan; ZHANG Kai-xuan; LIAO Yin-qian; LUO Fang; LUO Dan; ZOU Pin-ang; WANG Bao-guo

doi:10.16462/j.cnki.zhjbkz.2022.11.010

Volume 26 Issue 11

Nov. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(11): 1296-1302

LUO Jia-ze, HU Kuan, ZHANG Kai-xuan, LIAO Yin-qian, LUO Fang, LUO Dan, ZOU Pin-ang, WANG Bao-guo. Relationship between TAP2 gene polymorphism and susceptibility to pulmonary tuberculosis based on a case-control family study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(11): 1296-1302. doi: 10.16462/j.cnki.zhjbkz.2022.11.010

Citation:

LUO Jia-ze, HU Kuan, ZHANG Kai-xuan, LIAO Yin-qian, LUO Fang, LUO Dan, ZOU Pin-ang, WANG Bao-guo. Relationship between TAP2 gene polymorphism and susceptibility to pulmonary tuberculosis based on a case-control family study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(11): 1296-1302. doi: 10.16462/j.cnki.zhjbkz.2022.11.010

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Relationship between TAP2 gene polymorphism and susceptibility to pulmonary tuberculosis based on a case-control family study

doi: 10.16462/j.cnki.zhjbkz.2022.11.010

Department of Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China

Funds:

Guangzhou Science and Technology Program Project 202102080272

Special Fund Project for Scientific and Technological Innovation Cultivation of College Students in Guangdong pdjha0269

More Information

Corresponding author: WANG Bao-guo, E-mail:gdwangbaoguo@163.com
Received Date: 2022-03-11
Rev Recd Date: 2022-06-10

Available Online: 2022-12-21

Publish Date: 2022-11-10

Abstract

Abstract

Objective Pulmonary tuberculosis (PTB) infection has individual differences. To explore the effect of transporter-associated with antigen processing 2 (TAP2) gene polymorphism on pulmonary tuberculosis, and to analyze the interaction between TAP2 gene and demographic characteristics, behavioral factors and environmental factors in the pathogenesis of pulmonary tuberculosis. Methods Based on the case-control family study, patients with confirmed pulmonary tuberculosis in multiple pulmonary tuberculosis families collected by tuberculosis prevention and control units in Guangdong Province were selected as the case group. The healthy members in these families were included in the healthy household contacts (HHC) group, and the members of healthy families collected in the same period were included in the healthy controls (HC) group. Multivariate logistic regression model was used to analyze the association between the factors and pulmonary tuberculosis, and classification and regression tree (CART) model was used to analyze the interaction between risk factors of pulmonary tuberculosis. Results Multivariate logistic regression analysis showed that age, male, smoking and lack of fitness activities were risk factors of pulmonary tuberculosis for HHC group. For healthy controls, urban residence registration, BMI>18.5 kg/m² and indoor dryness were protective factors of pulmonary tuberculosis, while, male, smoking, lack of fitness activities and poor indoor environmental sanitation were risk factors. There was a significant correlation between rs3819721 and susceptibility to tuberculosis between PTB group and HHC group, PTB group and HC group. The CART model of PTB group and HHC group showed that co-existence of no smoking and fitness activities could significantly reduce the risk of tuberculosis. The CART model of PTB group and HC group showed that people who lacked fitness activities and carried AG+AA genotype had a higher risk of tuberculosis. Conclusions The gene polymorphism of TAP2 rs3819721 is associated with pulmonary tuberculosis. And there is an interaction between TAP2 rs3819721 and lack of fitness activities in the pathogenesis of pulmonary tuberculosis. The gene polymorphism of rs241447 has not been found to be related to the pathogenesis of pulmonary tuberculosis.
- Transporter-associated with antigen processing 2,
- Polymorphism,
- Pulmonary tuberculosis

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References(24)

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