Prevalence of dementia and its correlation with multimorbidity in community-dwelling older adults aged 65 and over in Hubei Province

ZHOU Fukai; TAN Wei; LIU Dan; CHENG Guirong; XU Lang; LIAN Pengfei; YANG Mengliu; YU Yafu; ZHANG Jingjing; ZENG Yan

doi:10.16462/j.cnki.zhjbkz.2023.06.002

Volume 27 Issue 6

Jun. 2023

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2023 > 27(6): 627-632

ZHOU Fukai, TAN Wei, LIU Dan, CHENG Guirong, XU Lang, LIAN Pengfei, YANG Mengliu, YU Yafu, ZHANG Jingjing, ZENG Yan. Prevalence of dementia and its correlation with multimorbidity in community-dwelling older adults aged 65 and over in Hubei Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 627-632. doi: 10.16462/j.cnki.zhjbkz.2023.06.002

Citation:

ZHOU Fukai, TAN Wei, LIU Dan, CHENG Guirong, XU Lang, LIAN Pengfei, YANG Mengliu, YU Yafu, ZHANG Jingjing, ZENG Yan. Prevalence of dementia and its correlation with multimorbidity in community-dwelling older adults aged 65 and over in Hubei Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 627-632. doi: 10.16462/j.cnki.zhjbkz.2023.06.002

Citation:

ZHOU Fukai, TAN Wei, LIU Dan, CHENG Guirong, XU Lang, LIAN Pengfei, YANG Mengliu, YU Yafu, ZHANG Jingjing, ZENG Yan. Prevalence of dementia and its correlation with multimorbidity in community-dwelling older adults aged 65 and over in Hubei Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 627-632. doi: 10.16462/j.cnki.zhjbkz.2023.06.002

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Prevalence of dementia and its correlation with multimorbidity in community-dwelling older adults aged 65 and over in Hubei Province

doi: 10.16462/j.cnki.zhjbkz.2023.06.002

1.
Medical College, Wuhan University of Science and Technology, Brain Science and Advanced Technology Institute, Wuhan University of Science and Technology, Wuhan 430065, China
2.
Neurology Department Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430065, China

Funds:

National Key Research and Development Program of China 2020YFC2006000

National Natural Science Foundation of China 72174159

More Information

Corresponding author: ZENG Yan, E-mail: zengyan68@wust.edu.cn
Received Date: 2022-11-07
Rev Recd Date: 2023-02-09

Available Online: 2023-07-10

Publish Date: 2023-06-10

Abstract

Abstract

Objective To investigate the prevalence and risk factors of dementia in community-dwelling older adults, with a specific focus on analyzing the association between multimorbidity and dementia. Methods The study participants were from the baseline survey (2018-2020) of the Hubei memory and aging cohort study (registration number: ChiCTR1800019164). According to the unified inclusion and exclusion criteria, a total of 8 221 elderly people ≥ 65 years old were included, who had completed a complete set of neuropsychological assessments and clinical physical examinations. The participants were divided into two groups according to their comorbidity status, including hypertension, diabetes, coronary heart disease, and cerebrovascular disease, i.e. non-comorbidity group (including having no chronic disease or only one disease), comorbidity group (having two or more chronic diseases). Multivariate logistic regression was used to analyze the risk factors for dementia based on residence. Results The standardized prevalence of dementia was 7.06% (95% CI: 6.40%-7.72%), 4.34% (95% CI: 3.81%-4.87%), and 11.53% (95% CI: 10.70%-12.35%) in the total population, urban population and rural population, respectively, and the prevalence of dementia in individuals with comorbidities was higher than that in those without comorbidities. Older age, no spouse, lack of physical activity, and lack of intellectual activity were risk factors for dementia. Multimordism was closely related to dementia. The risk of dementia in the comorbidity group was 1.299 times higher than that in the non-comorbidity group (OR=1.299, 95% CI: 1.079-1.563, P=0.006). Conclusions Dementia prevalence significantly increased with the presence of chronic disease comorbidity, with a noteworthy difference between rural and urban residents. This finding underscores the demand of dementia and multimorbidity interventions among community-dwelling elderly populations, suggesting the implementation of the family doctor system to mitigate dementia prevalence.
- Community elderly,
- Multimorbidity,
- Prevalence of dementia,
- Hubei memory and aging cohort study,
- Risk factor

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References(23)

References

[1]	Scheltens P, De Strooper B, Kivipelto M, et al. Alzheimer's disease[J]. Lancet, 2021, 397(10284): 1577-1590. DOI: 10.1016/S0140-6736(20)32205-4.
[2]	2021 Alzheimer's disease facts and figures[J]. Alzheimers Dement, 2021, 17(3): 327-406. DOI: 10.1002/alz.12328.
[3]	GBD 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019[J]. Lancet Public Health, 2022, 7(2): e105-e125. DOI: 10.1016/S2468-2667(21)00249-8.
[4]	Jia L, Quan M, Fu Y, et al. Dementia in China: epidemiology, clinical management, and research advances[J]. Lancet Neurol, 2020, 19(1): 81-92. DOI: 10.1016/S1474-4422(19)30290-X.
[5]	Dove A, Shang Y, Xu W, et al. The impact of diabetes on cognitive impairment and its progression to dementia[J]. Alzheimers Dement, 2021, 17(11): 1769-1778. DOI: 10.1002/alz.12482.
[6]	Kao SL, Wang JH, Chen SC, et al. Impact of comorbidity burden on cognitive decline: a prospective cohort study of older adults with dementia[J]. Dement Geriatr Cogn Disord, 2021, 50(1): 43-50. DOI: 10.1159/000514651.
[7]	Calderón-Larrañaga A, Vetrano DL, Onder G, et al. Assessing and measuring chronic multimorbidity in the older population: a proposal for its operationalization[J]. J Gerontol A Biol Sci Med Sci, 2017, 72(10): 1417-1423. DOI: 10.1093/gerona/glw233.
[8]	马丽媛, 王增武, 樊静, 等. 《中国心血管健康与疾病报告2021》概要[J]. 中国介入心脏病学杂志, 2022, 30(7): 481-496. DOI: 10.3969/j.issn.1004-8812.2022.07.001. Ma LY, Wang ZW, Fan J, et al. Summary of China cardiovascular health and disease report 2021[J]. Chin J Interv Cardiol, 2022, 30(7): 481-496. DOI: 10.3969/j.issn.1004-8812.2022.07.001.
[9]	Li L, Cheng GR, Liu D, et al. The Hubei memory and aging cohort study: study design, baseline characteristics, and prevalence of cognitive impairments[J]. J Alzheimers Dis, 2022, 85(2): 561-571. DOI: 10.3233/JAD-215129.
[10]	中国痴呆与认知障碍诊治指南写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会. 2018中国痴呆与认知障碍诊治指南(三): 痴呆的认知和功能评估[J]. 中华医学杂志, 2018, 98(15): 1125-1129. DOI: 10.3760/cma.j.issn.0376-2491.2018.15.002. The Writing Group of the Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Disorders in China, The Cognitive Disorders Professional Committee of the Neurologist Branch of the Chinese Medical Association. Guidelines for the diagnosis and treatment of dementia and cognitive impairment in China in 2018 (Ⅲ): cognitive and functional assessment of de-mentia[J]. Natl Med J China, 2018, 98(15): 1125-1129. DOI: 10.3760/cma.j.issn.0376-2491.2018.15.002.
[11]	Jia J, Zhou A, Wei C, et al. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese[J]. Alzheimers Dement, 2014, 10(4): 439-447. DOI: 10.1016/j.jalz.2013.09.008.
[12]	Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician[J]. J Psychiat Res, 1975, 12(3): 189-198. DOI: 10.1016/0022-3956(75)90026-6.
[13]	Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment[J]. J Am Geriatr Soc, 2005, 53(4): 695-699. DOI: 10.1111/j.1532-5415.2005.53221.x.
[14]	Chen KL, Xu Y, Chu AQ, et al. Validation of the Chinese version of Montreal cognitive assessment basic for screening mild cognitive impairment[J]. J Am Geriatr Soc, 2016, 64(12): e285-e290. DOI: 10.1111/jgs.14530.
[15]	Stricker NH, Lundt ES, Albertson SM, et al. Diagnostic and prognostic accuracy of the cogstate brief battery and auditory verbal learning test in preclinical Alzheimer's disease and incident mild cognitive impairment: implications for defining subtle objective cognitive impairment[J]. J Alzheimers Dis, 2020, 76(1): 261-274. DOI: 10.3233/JAD-200087.
[16]	Knesevich JW, LaBarge E, Edwards D. Predictive value of the Boston Naming Test in mild senile dementia of the Alzheimer type[J]. Psychiatry Res, 1986, 19(2): 155-161. DOI: 10.1016/0165-1781(86)90008-9.
[17]	Leung JL, Lee GT, Lam YH, et al. The use of the Digit Span Test in screening for cognitive impairment in acute medical inpatients[J]. Int Psychogeriatr, 2011, 23(10): 1569-1574. DOI: 10.1017/S1041610211000792.
[18]	Yang T, Deng Q, Jiang S, et al. Cognitive impairment in two subtypes of a single subcortical infarction[J]. Chin Med J (Engl), 2021, 134(24): 2992-2998. DOI: 10.1097/CM9.0000000000001938.
[19]	Miebach L, Wolfsgruber S, Polcher A, et al. Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study[J]. Alzheimers Res Ther, 2019, 11(1): 66. DOI: 10.1186/s13195-019-0515-y.
[20]	中国痴呆与认知障碍诊治指南写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会. 2018中国痴呆与认知障碍诊治指南(五): 轻度认知障碍的诊断与治疗[J]. 中华医学杂志, 2018, 98(17): 1294-1301. DOI: 10.3760/cma.j.issn.0376-2491.2018.17.003. The Writing Group of the Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Disorders in China, The Cognitive Disorders Professional Committee of the Neurologist Branch of the Chinese Medical Association. Guidelines for the diagnosis and treatment of dementia and cognitive impairment in China in 2018 (Ⅴ): diagnosis and treatment of mild cognitive impairment[J]. Natl Med J China, 2018, 98(17): 1294-1301. DOI: 10.3760/cma.j.issn.0376-2491.2018.17.003.
[21]	Jia L, Du Y, Chu L, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study[J]. Lancet Public Health, 2020, 5(12): e661-e671. DOI: 10.1016/S2468-2667(20)30185-7.
[22]	祝云龙, 余珊珊, 张玲, 等. 衢州市60岁及以上人群痴呆患病情况及危险因素调查研究[J]. 重庆医学, 2019, 48(21): 3715-3719. DOI: 10.3969/j.issn.1671-8348.2019.21.027. Zhu YL, Yu SS, Zhang L, et al. Investigation and study on prevalence situation and risk factors of dementiain population aged 60 years old and over in Quzhou City[J]. Chongqing Medical Journal, 2019, 48(21): 3715-3719. DOI: 10.3969/j.issn.1671-8348.2019.21.027.
[23]	De Deyn PP, Goeman J, Vervaet A, et al. Prevalence and incidence of dementia among 75-80-year-old community-dwelling elderly in different districts of Antwerp, Belgium: the Antwerp Cognition (ANCOG) Study[J]. Clin Neurol Neurosurg, 2011, 113(9): 736-745. DOI: 10.1016/j.clineuro.2011.07.030.