Analysis of liver dysfunction and its influencing factors in middle-aged and elderly people in Hainan Province

ZHANG Tao; LIN Guotian; LIN Liuting; ZHAO Chanjuan; ZHANG Fan

doi:10.16462/j.cnki.zhjbkz.2023.06.004

Volume 27 Issue 6

Jun. 2023

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ZHANG Tao, LIN Guotian, LIN Liuting, ZHAO Chanjuan, ZHANG Fan. Analysis of liver dysfunction and its influencing factors in middle-aged and elderly people in Hainan Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 639-644. doi: 10.16462/j.cnki.zhjbkz.2023.06.004

Citation:

ZHANG Tao, LIN Guotian, LIN Liuting, ZHAO Chanjuan, ZHANG Fan. Analysis of liver dysfunction and its influencing factors in middle-aged and elderly people in Hainan Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 639-644. doi: 10.16462/j.cnki.zhjbkz.2023.06.004

Citation:

ZHANG Tao, LIN Guotian, LIN Liuting, ZHAO Chanjuan, ZHANG Fan. Analysis of liver dysfunction and its influencing factors in middle-aged and elderly people in Hainan Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 639-644. doi: 10.16462/j.cnki.zhjbkz.2023.06.004

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Analysis of liver dysfunction and its influencing factors in middle-aged and elderly people in Hainan Province

doi: 10.16462/j.cnki.zhjbkz.2023.06.004

1.
Department of Nutrition and Food Hygiene, International School of Public Health and One Health, Hainan Medical University, Haikou 571199, China
2.
Department of Health Statistics, International School of Public Health and One Health, Hainan Medical University, Haikou 571199, China

Funds:

National Key Research and Development Program of China 2017YFC0907104

National Natural Science Foundation of China 81860577

More Information

Corresponding author: ZHANG Fan, E-mail: zhangfan@hainmc.edu.cn
Received Date: 2022-07-29
Rev Recd Date: 2022-12-06

Available Online: 2023-07-10

Publish Date: 2023-06-10

Abstract

Abstract

Objective The aim of this study is to assess the prevalence of liver dysfunction among middle-aged and elderly people in Hainan and identify its associated factors. Methods This study is based on the baseline survey from the "Prospective Cohort Study of Chronic Diseases in Hainan Natural Population" in 2020, comprising 5 826 permanent residents aged 35- < 75 years in Hainan. Liver dysfunction prevalence and distribution data were collected via questionnaire surveys, and liver dysfunction indicators: alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyltransferase (GGT) were obtained through blood biochemical tests. The related factors of liver dysfunction were analyzed by χ² test and binary logistic regression analysis model. Results Among 5 826 subjects, the prevalence of liver dysfunction was 22.6% (1 318/5 826). There were statistic significant differences between liver dysfunction and variables such as gender, nationality, age, geographical location, education level, occupation, smoking and drinking habits, chronic disease status, drug intake, place of residence, and sleep satisfaction (all P < 0.05). Multivariate logistic regression showed that being male (OR=5.239, 95% CI: 4.189-6.552), belonging to Li nationality (OR=3.510, 95% CI: 2.233-5.517), being elderly (OR=1.015, 95% CI: 1.006-1.024), drug intake (OR=1.717, 95% CI: 1.284-2.295), rural residents (OR=1.931, 95% CI: 1.570-2.375), smoking [occasional versus non-smoking, 1.503 (1.210-1.866); regular versus non-smoking, 1.606 (1.330-1.940)], drinking [occasional versus non-drinking, 2.127 (1.733-2.611); regular versus non-drinking, 3.123 (2.493-3.915)] were main risk factors of liver dysfunction. Conclusions The prevalence of liver dysfunction is notably high among residents aged 35-74 years in Hainan. The main risk factors are age, gender, ethnicity (Li), drug intake, residing in rural areas, and habits of smoking and drinking. It is suggested to amplify health education efforts among the elderly and ethnic minority regions in Hainan Province.
- Liver dysfunction,
- Hainan Province,
- Risk factors,
- Cross-sectional study

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References(23)

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