Construction and validation of a risk assessment model for mild cognitive impairment in Chinese elderly based on Meta-analysis

ZHANG Yifang; ZHANG Haixin; ZHANG Wenling; QU Yimin; JIANG Yu; LI Jinlei

doi:10.16462/j.cnki.zhjbkz.2023.06.015

Volume 27 Issue 6

Jun. 2023

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2023 > 27(6): 705-710

ZHANG Yifang, ZHANG Haixin, ZHANG Wenling, QU Yimin, JIANG Yu, LI Jinlei. Construction and validation of a risk assessment model for mild cognitive impairment in Chinese elderly based on Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 705-710. doi: 10.16462/j.cnki.zhjbkz.2023.06.015

Citation:

ZHANG Yifang, ZHANG Haixin, ZHANG Wenling, QU Yimin, JIANG Yu, LI Jinlei. Construction and validation of a risk assessment model for mild cognitive impairment in Chinese elderly based on Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 705-710. doi: 10.16462/j.cnki.zhjbkz.2023.06.015

Citation:

ZHANG Yifang, ZHANG Haixin, ZHANG Wenling, QU Yimin, JIANG Yu, LI Jinlei. Construction and validation of a risk assessment model for mild cognitive impairment in Chinese elderly based on Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(6): 705-710. doi: 10.16462/j.cnki.zhjbkz.2023.06.015

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Construction and validation of a risk assessment model for mild cognitive impairment in Chinese elderly based on Meta-analysis

doi: 10.16462/j.cnki.zhjbkz.2023.06.015

Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2021-JKCS-023

More Information

Corresponding author: JIANG Yu, E-mail: jiangyu@pumc.edu.cn; LI Jinlei, E-mail: lijinlei@sph.pumc.edu.cn
Received Date: 2022-10-11
Rev Recd Date: 2023-01-11

Available Online: 2023-07-10

Publish Date: 2023-06-10

Abstract

Abstract

Objective To establish a risk assessment model for mild cognitive impairment (MCI) in elderly Chinese individuals and verify the effect of the model. Methods Meta-analysis was used to derive influencing factors and exposure rates for MCI in the Chinese elderly from existing literature. The Rothman-Keller model was used to construct the risk assessment model of MCI in the Chinese elderly population. Verification data were collected from the Health Examination Center of Penglai People′s Hospital and Rongcheng People′s Hospital of Shandong Province, spanning November 2021 to June 2022, and encompassed 2 545 elderly people aged 60 and above. The model′s efficacy was verified by calculating the area under the curve (AUC), sensitivity, and specificity of the receiver operating characteristic (ROC) curve using Stata 17.0. Results A total of 49 articles were included in the Meta-analysis. Gender, age, family history of dementia, education, smoking, drinking, exercise, living alone, insomnia, overweight/obesity, hypertension, hyperlipidemia, diabetes, cardiovascular diseases, and cerebrovascular diseases were included to establish the Rothman-Keller model. The AUC of the model was 0.772, and the sensitivity and specificity were 78.04% and 63.95%, respectively. Conclusions The MCI risk assessment model established in this study proved effective for the elderly population in China. With its high sensitivity, this model can be used to identify MCI in the community population, facilitating early detection of high-risk people and enabling proactive measures to prevent the development of MCI and dementia.
- Mild cognitive impairment,
- Meta analysis,
- Rothman-Keller model,
- Risk assessment

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References(29)

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