Associations between polycyclic aromatic hydrocarbon exposure and human papillomavirus infection in women with abnormal cervical cytology

ZHANG Le; ZHANG Mingxuan; WANG Jiahao; WU Caihong; PEI Ruixin; YAN Jiaxin; LYU Yuanjing; SONG Li; CUI Meng; DING Ling; HAO Min; WANG Jintao

doi:10.16462/j.cnki.zhjbkz.2023.07.012

Volume 27 Issue 7

Jul. 2023

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2023 > 27(7): 814-820

ZHANG Le, ZHANG Mingxuan, WANG Jiahao, WU Caihong, PEI Ruixin, YAN Jiaxin, LYU Yuanjing, SONG Li, CUI Meng, DING Ling, HAO Min, WANG Jintao. Associations between polycyclic aromatic hydrocarbon exposure and human papillomavirus infection in women with abnormal cervical cytology[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(7): 814-820. doi: 10.16462/j.cnki.zhjbkz.2023.07.012

Citation:

ZHANG Le, ZHANG Mingxuan, WANG Jiahao, WU Caihong, PEI Ruixin, YAN Jiaxin, LYU Yuanjing, SONG Li, CUI Meng, DING Ling, HAO Min, WANG Jintao. Associations between polycyclic aromatic hydrocarbon exposure and human papillomavirus infection in women with abnormal cervical cytology[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(7): 814-820. doi: 10.16462/j.cnki.zhjbkz.2023.07.012

Citation:

ZHANG Le, ZHANG Mingxuan, WANG Jiahao, WU Caihong, PEI Ruixin, YAN Jiaxin, LYU Yuanjing, SONG Li, CUI Meng, DING Ling, HAO Min, WANG Jintao. Associations between polycyclic aromatic hydrocarbon exposure and human papillomavirus infection in women with abnormal cervical cytology[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2023, 27(7): 814-820. doi: 10.16462/j.cnki.zhjbkz.2023.07.012

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Associations between polycyclic aromatic hydrocarbon exposure and human papillomavirus infection in women with abnormal cervical cytology

doi: 10.16462/j.cnki.zhjbkz.2023.07.012

1.
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China
2.
Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China

Funds:

National Natural Science Foundation of China 81872705

National Natural Science Foundation of China 81473060

National Natural Science Foundation of China 81703313

Nonprofit Scientific Research Industry Special Fund of National Health and Family Planning Commission of China 201402010

More Information

Corresponding author: WANG Jintao, E-mail: wangjt59@163.com
Received Date: 2022-07-12
Rev Recd Date: 2022-10-02

Available Online: 2023-08-08

Publish Date: 2023-07-10

Abstract

Abstract

Objective This study aimed to explore the association between polycyclic aromatic hydrocarbons (PAHs) exposure and human papillomavirus (HPV) infection in women with abnormal cervical cytology. Methods A cross-sectional study was conducted on a cohort of 2 285 women with abnormal cervical cytology.The cohort was previously established by our research group.The study analyzed the association between PAHs and HPV infection, using HPV infection status in cervical exfoliated cells and 1-hydroxypyrene (1-OHP) exposure levels in urine detected at the same time. Results In women with abnormal cervical cytology, the HPV infection rate was 32.3%, with single and multiple infection rates of 22.8% and 9.4%, respectively.The infection rate of high-risk HPV (HR-HPV) was 31.6%, and the top five infection types were HPV16, HPV58, HPV52, HPV53, and HPV51.The exposure levels of PAHs in women infected with HPV and its single or multiple, HR-HPV, HPV16, HPV58, HPV52, HPV53, and HPV51 were all higher than those without infection (all P < 0.001).High exposure to PAHs could increase the risk of infection of the above types of HPV, showing a dose-response relationship between PAHs exposure levels and the risk of HPV infection (all P < 0.05).Further stratified analysis showed that among women aged 35- < 45 years, with junior high school education level or below, passive smoking, premenopausal women and parities ≥3 times, the risk of HPV infection and high-risk HPV16 infection was greater in those with high PAHs exposure. Conclusions High exposure to PAHs could increase the risk of HPV or high-risk HPV infection in women with cervical cell abnormalities, especially in women aged 35- < 45 years, with low education level, passive smoking, multiple parturition, and premenopausal women.
- Abnormal cervical cytology,
- Polycyclic aromatic hydrocarbons,
- Human papillomavirus,
- Stratified analysis

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References(24)

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