Association between fasting blood glucose trajectories and new-onset cardiovascular diseases in the elderly health check-up population in Nanjing

CHEN Quan; DU Jinling; HONG Xin

doi:10.16462/j.cnki.zhjbkz.2024.03.005

Volume 28 Issue 3

Mar. 2024

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CHEN Quan, DU Jinling, HONG Xin. Association between fasting blood glucose trajectories and new-onset cardiovascular diseases in the elderly health check-up population in Nanjing[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 277-283. doi: 10.16462/j.cnki.zhjbkz.2024.03.005

Citation:

CHEN Quan, DU Jinling, HONG Xin. Association between fasting blood glucose trajectories and new-onset cardiovascular diseases in the elderly health check-up population in Nanjing[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 277-283. doi: 10.16462/j.cnki.zhjbkz.2024.03.005

Citation:

CHEN Quan, DU Jinling, HONG Xin. Association between fasting blood glucose trajectories and new-onset cardiovascular diseases in the elderly health check-up population in Nanjing[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 277-283. doi: 10.16462/j.cnki.zhjbkz.2024.03.005

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Association between fasting blood glucose trajectories and new-onset cardiovascular diseases in the elderly health check-up population in Nanjing

doi: 10.16462/j.cnki.zhjbkz.2024.03.005

CHEN Quan^{1, 2},
DU Jinling²,
HONG Xin^{1, 2
,
,}

1.
Nanjing Center for Disease Control and Prevention, Nanjing Medical University, Nanjing 210003, China
2.
School of Public Health, Nanjing Medical University, Nanjing 211166, China

Funds:

Jiangsu Provincial Health and Health Commission 2022 Medical Research Projects M2022028

More Information

Corresponding author: HONG Xin, E-mail: nj_hongxin@126.com
Received Date: 2023-07-04
Rev Recd Date: 2023-09-29

Available Online: 2024-04-08

Publish Date: 2024-03-10

Abstract

Abstract

Objective To investigate the association between fasting blood glucose trajectory and the incidence of cardiovascular disease among the elderly population aged 65 years and above in Nanjing. Methods A total of 7 079 participants were included from the Nanjing elderly health checkup cohort who met the inclusion criteria. The trajectory of fasting plasma glucose(FPG) index (FPG was taken as its logarithm to make it obey normal distribution) was constructed by group-based trajectory model (GBTM) over the years from 2018 to 2020. And we followed up the incidence of cardiovascular disease in 2021. A Cox regression model was used to analyze the association between distinct trajectory groups and the incidence of cardiovascular disease. Results The FPG trajectory was finally divided into low-level group (5 635, 79.6%), medium-level group (1 201, 17.0%) and high-level group (243, 3.4%). A total of 70 cases of cardiovascular disease were newly reported during the follow-up period, with the low, medium, and high level groups accounting for 0.83%, 1.42%, and 2.47% of the new cases in the group, respectively. The incidence of cardiovascular disease increased with increasing FPG levels (trend χ² =8.750, P=0.003), and the difference was statistically significant (χ² =9.050, P=0.011). The Cox regression model showed that the risk of cardiovascular disease in the high-level group was 2.96 times higher than that in the low-level group (95% CI: 1.27-6.92). Conclusions Long-term high levels of FPG increase the risk of cardiovascular disease in the elderly, so timely intervention and early prevention are warranted.
- Elderly population,
- Fasting plasma glucose,
- Trajectory,
- Cardiovascular disease,
- Cohort study

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References(31)

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