A cross-sectional study of Helicobacter pylori infection and metabolic syndrome

CHEN Yuanyuan; HU Zhiqiang; HU Jingcen; WU Yaxian; MA Zheng; LYU Jun; SUN Dianjianyi; MAN Sailimai; WANG Xiaona; WANG Bo; YU Canqing; LI Liming

doi:10.16462/j.cnki.zhjbkz.2024.03.015

Volume 28 Issue 3

Mar. 2024

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2024 > 28(3): 339-344

CHEN Yuanyuan, HU Zhiqiang, HU Jingcen, WU Yaxian, MA Zheng, LYU Jun, SUN Dianjianyi, MAN Sailimai, WANG Xiaona, WANG Bo, YU Canqing, LI Liming. A cross-sectional study of Helicobacter pylori infection and metabolic syndrome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 339-344. doi: 10.16462/j.cnki.zhjbkz.2024.03.015

Citation:

CHEN Yuanyuan, HU Zhiqiang, HU Jingcen, WU Yaxian, MA Zheng, LYU Jun, SUN Dianjianyi, MAN Sailimai, WANG Xiaona, WANG Bo, YU Canqing, LI Liming. A cross-sectional study of Helicobacter pylori infection and metabolic syndrome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 339-344. doi: 10.16462/j.cnki.zhjbkz.2024.03.015

Citation:

CHEN Yuanyuan, HU Zhiqiang, HU Jingcen, WU Yaxian, MA Zheng, LYU Jun, SUN Dianjianyi, MAN Sailimai, WANG Xiaona, WANG Bo, YU Canqing, LI Liming. A cross-sectional study of Helicobacter pylori infection and metabolic syndrome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 339-344. doi: 10.16462/j.cnki.zhjbkz.2024.03.015

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A cross-sectional study of Helicobacter pylori infection and metabolic syndrome

doi: 10.16462/j.cnki.zhjbkz.2024.03.015

CHEN Yuanyuan¹,
HU Zhiqiang²,
HU Jingcen¹,
WU Yaxian¹,
MA Zheng^{3, 5},
LYU Jun^{1, 3, 4, 5},
SUN Dianjianyi^{1, 3, 4, 5},
MAN Sailimai^{1, 5, 6},
WANG Xiaona⁷,
WANG Bo^{3, 5, 6
,
,},
YU Canqing^{1, 3, 4, 5
,
,},
LI Liming^{1, 3, 4, 5}

1.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China
2.
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China
3.
Peking University Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing 100191, China
4.
Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China
5.
Peking University Health Science Center Meinian Public Health Institute, Beijing 100191, China
6.
Meinian Institute of Health, Beijing 100191, China
7.
Beijing MJ Health Screening Center, Beijing 100006, China

Funds:

National Natural Science Foundation of China 82192900

National Natural Science Foundation of China 82192901

National Natural Science Foundation of China 82192904

More Information

Corresponding author: WANG Bo, E-mail: paul@meinianresearch.com; YU Canqing, E-mail: yucanqing@pku.edu.cn
Received Date: 2023-08-04
Rev Recd Date: 2024-01-06

Available Online: 2024-04-08

Publish Date: 2024-03-10

Abstract

Abstract

Objective To understand the cross-sectional association of Helicobacter pylori (H. pylori) infection with metabolic syndrome (MetS) and its four components among residents with health checkups in Beijing. Methods Participants aged 18 or older who attended health checkups at Beijing MJ Health Screening Center during 2009-2020 were included. The H. pylori infection status was identified by the ¹³C-urea breath test. The diagnoses of MetS and its four components (abdominal obesity, hyperglycemia, high blood pressure, and dyslipidemia) were defined according to the Joint Committee for Developing Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. Multivariate logistic regression was performed to estimate the OR and 95% CI. Results Among the 31 369 participants, 58.7% were men, and the mean age was (45.3±11.6) years. The H. pylori-positive rate was 35.7%, and the prevalence rate of MetS was 25.6%. The overall prevalence of MetS in males was higher than in females. After adjusting for potential confounders, participants infected with H. pylori had elevated risks of MetS (OR=1.18, 95% CI: 1.11-1.25, P<0.001) and its four components. The ORs for abdominal obesity (OR=1.18, 95% CI: 1.11-1.24, P<0.001) and dyslipidemia (OR=1.14, 95% CI: 1.06-1.22, P<0.001) were higher. The association for dyslipidemia was stronger among females than males (P=0.003). Conclusions H. pylori infection is remarkably correlated with increased risks of MetS and its components after adjusting for potential confounders.
- Helicobacter pylori,
- Metabolic syndrome,
- Cross-sectional study

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References(20)

References

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