Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly

WU Yinru; ZHONG Yishi; GAO Jian; CHEN Peiliang; YOU Fangfei; SONG Weiqi; MAO Chen

doi:10.16462/j.cnki.zhjbkz.2024.03.020

Volume 28 Issue 3

Mar. 2024

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WU Yinru, ZHONG Yishi, GAO Jian, CHEN Peiliang, YOU Fangfei, SONG Weiqi, MAO Chen. Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2024.03.020

Citation:

WU Yinru, ZHONG Yishi, GAO Jian, CHEN Peiliang, YOU Fangfei, SONG Weiqi, MAO Chen. Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2024.03.020

Citation:

WU Yinru, ZHONG Yishi, GAO Jian, CHEN Peiliang, YOU Fangfei, SONG Weiqi, MAO Chen. Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2024.03.020

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Association between plasma levels of IL-6 and TNF-α and mild cognitive impairment in the elderly

doi: 10.16462/j.cnki.zhjbkz.2024.03.020

Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China

Funds:

National Natural Science Foundation of China 81973109

More Information

Corresponding author: MAO Chen, E-mail: maochen9@smu.edu.cn
Received Date: 2023-08-29
Rev Recd Date: 2024-01-10

Available Online: 2024-04-08

Publish Date: 2024-03-10

Abstract

Abstract

Objective To analyze the association between plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and mild cognitive impairment (MCI) in elderly individuals aged 65 years and older in Guangdong. Methods A total of 48 MCI elderly patients who visited a community health service center in Guangdong were selected as the case group, while 96 non-MCI individuals served as controls. Logistic regression models were used to analyze the association between plasma levels of IL-6 and TNF-α and MCI. Receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic value of plasma levels of IL-6 and TNF-α for MCI. Results A total of 144 elderly individuals were enrolled, including 48 MCI patients and 63 males (43.8%). The results of the multivariate logistic regression models showed that increased plasma levels of IL-6 and TNF-α could lead to a higher risk of MCI. Specifically, the risk of MCI increased by 53% and 51% for each standard deviation increase in plasma levels of IL-6 and TNF-α, respectively (OR=1.53, 95% CI: 1.02-2.29, P=0.040; OR=1.51, 95% CI: 1.04-2.20, P=0.029). The areas under the ROC curves for IL-6 and TNF-α were 0.60 and 0.64, respectively. Conclusions The increased risk of MCI in individuals aged 65 years and older may be associated with elevated plasma levels of IL-6 and TNF-α.
- Elderly,
- Mild cognitive impairment,
- Interleukin-6,
- Tumor necrosis factor-α,
- Case-control study

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References(13)

References

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