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CN 34-1304/R ISSN 1674-3679

2018 Vol. 22, No. 9

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Identification of risk factors for cardiovascular diseases based on multi-omics studies
2018, 22(9): 873-874,879. doi: 10.16462/j.cnki.zhjbkz.2018.09.001
Abstract(535) PDF(67)
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Cardiovascular diseases (CVD) are leading causes of death in China. Complex and dynamic networks of molecules are involved in CVD. As compared to studies of a single omics type, multi-omics offers the opportunity to understand the flow of information that underlies disease. To improve prevention and control standards of CVD in China, we need to carry out multi-omics studies in prospective cohorts to find additional risk factors and elucidate the disease mechanisms.
Association between family history and hypertension in Han population of Gansu Province
MO Xing-bo, ZHANG Yong-hong
2018, 22(9): 875-879. doi: 10.16462/j.cnki.zhjbkz.2018.09.002
Abstract(628) PDF(51)
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Objective To investigate the prevalence of hypertension and its association with family history (FH) in Han people aged 20-80 living in Gansu Province. Methods By performing a multi-stage stratified clustering sampling method, 4 247 Han people resident in four sites in Gansu Province were selected as study participants. All participants underwent face to face questionnaire interview, physical examination and biochemical tests. Results A total of 4 247 Han subjects aged 20-80 years were included, among which 1 777 (41.8%) were men and 2 470 (58.2%) were women. The response rate and the eligibility rate were 97.4% and 98.7%, respectively. The crude prevalence of hypertension was 28.2%. Along with elevated FH categories, participants had increased prevalence of hypertension. The multi-variable logistic regression analysis indicated that after adjusting for age, sex, current residential area, body mass index (BMI), educational level, tobacco use, alcohol consumption, physical activity and diabetes, participants with FH had 3.36 times higher (OR=3.36,95% CI:2.58-4.41,P<0.001) than those without FH of hypertension. The risk of hypertension also increased with the number of affected generations(one:OR=2.33, 95% CI:1.77-3.09, P<0.001; two:OR=5.97, 95% CI:4.42-8.13, P<0.001; three:OR=14.64, 95% CI:8.30-26.27, P<0.001). Conclusions The prevalence of hypertension is higher in people with hypertension family history. As FH categories increase, a consistent trend of increasing hypertension prevalence is observed. Since individual with FH of hypertension can be easily identified, screening and targeted intervention toward this population may improve the prevention of hypertension.
Association analysis of self-management behaviors and blood pressure control in patients with hypertension based on latent profile analysis
YU Cheng-dong, PAN Li, REN Xiao-lan, ZHANG Jia, ZHAO Hong-jun, WANG Xiao-yang, CHANG Li-jun, TUO Ya
2018, 22(9): 880-883,911. doi: 10.16462/j.cnki.zhjbkz.2018.09.003
Abstract(412) PDF(43)
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Objective To investigate the characteristics of self-management behaviors in patients with hypertension based on latent profile analysis (LPA), and to analyze the association between self-management behaviors and blood pressure control. Methods A total of 595 hypertensive patients were enrolled from eight community health service centers in Shunyi District of Beijing. The questionnaire including demographic characteristics and self-management behaviors, and physical examination including blood pressure measurement were used to conduct the survey. Results Patients were divided into two categories based on LPA of self-management behaviors:the worse group including 100 patients (16.8%) and the better group including 495 patients (83.2%). The two groups were mainly profiled by smoking (mean score was 0.15 vs 6.94) and drinking (mean score was 2.32 vs 6.43). And there were significant difference in gender (χ2=163.290, P<0.001) and hypertension medication history (Z=-2.567, P=0.010). The worse group mainly contained male patients and patients with less than 5 years of medication history, while the better group was characterized by female and 10-19 years of medication history. Binary Logistic regression analysis about blood pressure control showed that:compared to patients with New Rural Cooperative Medical Scheme, the blood pressure control was better in patients with Urban Residents Basic Medical Insurance and Ultra Personnel Medical Insurance (OR=2.618, 95% CI:1.549-4.423), and with Socialized medicine and Urban Employees Basic Medical Insurance (OR=3.449, 95% CI:2.196-5.415); compared to patients in the better group, the blood pressure control was poorer in patients of the worse group (OR=0.495, 95% CI:0.311-0.788). Conclusions Self-management behaviors of patients with hypertension are mainly classified by smoking and drinking. Interventions on self-management behaviors should be taken for male patients and for patients with shorter hypertension medication history. The attention and management for patients with New Rural Cooperative Medical Scheme and patients with poor self-management behaviors should be strengthened.
A comparative study of the injuries mortality among children under 5 years old between China and Kazakhstan from 2000 to 2015
HU Kang, ZHANG Xing, ZHU Xiao-rou, SHEN Ying, WANG Feng-bin
2018, 22(9): 884-888. doi: 10.16462/j.cnki.zhjbkz.2018.09.004
Abstract(386) PDF(57)
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Objective To analyze the characteristics of changes in the deaths of injuries among children under 5 years old between China and Kazakhstan from 2000 to 2015, in order to promote the common prevention of child injury in the countries along the belt and road initiative. Methods The data of injuries mortality among children under 5 years old from 2000 to 2015 were got from global health observational database on the net of world health organization. The dynamic distribution of the injuries mortality were described and analyzed. Results During the past 16 years, the injuries mortality rates of children under 5 years old in China and Kazakhstan both showed a downward trend. The average rate of decline was 6.14% annually in China and it was lower than that of global level after 2010; the average rate decreased by 5.14% annually in Kazakhstan and it was consistently lower than that of global level. Traffic accidents and drowning were both among the top three causes of death in injuries for children under 5 years old in both countries. The death rates of these two types of injuries in China had declined significantly over the past 16 years. The proportion of mechanical injuries increased while the proportion of violent injuries decreased in both countries (all P<0.05). Injuries mortality rates of boys was higher than that of girls among children under 5 years old (all P<0.05), but there was no significant difference in the degree of the rate of decline in injury deaths within the same stage of years in both countries (all P>0.05). Conclusions In the past 16 years, the effectiveness of prevention and control of injuries among children under 5 years old were more remarkable in China and Kazakhstan compared with the global average level. The prevention and control of the injury mortality between boys and girls reflected the fairness of health services in the two countries. China's prevention and control measures for traffic accidents and drowning injuries are worth learning. Further prevention and control are needed to focus on the key issues of major types of injury in both countries.
The impact of parenting style on children's sport injury: the role of child temperament as a mediator
CHANG Pu, LI Yan-fen, HOU Zhe, LI Jia-jia, PEI Hong-bo
2018, 22(9): 889-892. doi: 10.16462/j.cnki.zhjbkz.2018.09.005
Abstract(546) PDF(40)
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Objective To explore the mediating role of child temperament in parental rearing style and children's sport injury, and to provide a theoretical basis for the prevention of children's sport injury. Methods Totally 2 212 students in grade 4 and 5 from 8 primary schools in Taiyuan City were selected by using stratified random cluster sampling method and surveyed with questionnaire. Results The incidence of sport injury was 33.3%. The incidence of sport injury in boys (37.9%) was higher than that of girls (28.2%)(χ2=22.688,P<0.001). In addition to FFI (the father's emotional warmth and understanding), the higher the scores, the greater the likelihood that children would be injured (all P<0.05). The higher the score of activity level, rhythmicity, reaction intensity, emotional nature and persistence, the greater the possibility of children's sports injury (all P<0.05). Child temperament had some mediating effect between active parenting style and sport injury, the mediating effect accounted for 10.8% of the total effects. Child temperament had some mediating effect between negative parenting style and sport injury, the mediating effect accounted for 9.4% of the total effects. Conclusions Parenting styles and temperament have significant influence on the occurrence of sport injury, therefore, parents should identify the high-risk groups and take appropriate parenting to reduce the rate and severity of sport injury.
Epidemiological analysis on temporal trend of injury mortality in Jiading District, Shanghai from 1991 to 2014
MA Zi-fang, TANG Ying, HU Rui-jie, XUE Zhong-yu, WANG Li, LI Ji
2018, 22(9): 893-896,901. doi: 10.16462/j.cnki.zhjbkz.2018.09.006
Abstract(486) PDF(57)
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Objective To investigate the dynamic pattern of injury during 1991-2014 in Jiading District, Shanghai, and to analyze the characteristic of major injury causes that influence men and women in different age groups. Methods The injury death cases from the death registry system were used in our study. Percent change and average annual percent change were used to analyze the temporal trend of injury death. The constituent ratios and age-standardized mortalities were calculated to assess the relative importance, age distribution and gender disparity.Results From 1991 to 2014, a total of 6 722 people died of injuries in Jiading District. The corresponding constituent ratio and age-standardized mortality were 7.26% and 36.37/100 000, respectively. The age-standardized mortality of men was higher than women and people aged 15 to 35 years were most affected by injury. Transport accidents and suicide were the major causes influencing people aged 15 to 35 years.Conclusion The mortality of injury declined during the study period. It's still urgent and important to strengthen the prevention of transport accidents in men aged 15 to 35 years, suicide in women aged 15 to 35 years and accidental falls in people aged more than 65 years.
Spatial distribution characteristics and spatial autocorrelation analysis of human brucellosis in Shandong Province from 2014 to 2016
SHAO Yue-qin, ZHU Cheng-hua, WANG Na, YU Hong-jie
2018, 22(9): 897-901. doi: 10.16462/j.cnki.zhjbkz.2018.09.007
Abstract(581) PDF(65)
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Objective To analyze the spatial distribution and spatial clustering of human brucellosis in Shandong Province from 2014 to 2016, and to provide scientific evidence for developing the targeted strategies and measures for the prevention and control of human brucellosis. Methods Based on GeoDA1.8.16 software, the global and local spatial autocorrelation analysis were used to analyze the data on human brucellosis in Shandong Province during the period of 2014-2016. Results A total of 10 630 brucellosis cases were reported during 2014-2016 in Shandong Province, and the incidence increased from 2.91/100 000(2 845 cases) to 4.03/100 000(4 009 cases),with the annual average incidence of 3.59/100 000,and showing an increasing trend on annual incidence (χternd2=172.87, P<0.001).The epidemic range of human brucellosis distributed in 136 counties (cities or areas). The spatial autocorrelation analysis showed that Global Moran's I index for the incidence were 0.323, 0.300 and 0.179 respectively, and were all positive (all P<0.05), suggesting that there was a significant spatial clustering of human brucellosis during 2014-2016. Global Moran's I index decreased year by year (all P<0.05), suggesting decreased spatial clustering of human brucellosis during 2014-2016.The local autocorrelation analysis showed that high-high clustering areas were mainly distributed in the central and northern parts of Shandong, with consistent high morbidity. Counties or districts that located in the eastern coastal parts of Shandong presented the low-low relation. Conclusions The annual reported brucellosis incidence increased year by year in Shandong during 2014-2016, and the incidence of human brucellosis was non-randomly distributed. A positive spatial correlation and significant spatial clustering were found in the distribution of human brucellosis and the high-high clustered areas mainly distributed in the central and northern areas of Shandong, indicating that it is necessary to strengthen the prevention and control efforts in these areas.
Molecular characteristics of the hemagglutinin and neuraminidase genes of influenza A/H3N2 viruses isolated in Yancheng City from 2015 to 2017
LIU Wei-liang, KOU Zeng-qiang, CHEN Bao-li, BI Zhen-wang
2018, 22(9): 902-907. doi: 10.16462/j.cnki.zhjbkz.2018.09.008
Abstract(454) PDF(46)
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Objective To analyze the genetic characteristics of the hemagglutinin and neuraminidase genes of influenza A/H3N2 viruses isolated in Yancheng City from 2015 to 2017. Methods From 2015 to 2017, a total of 3 891 influenza-like specimens from the Yancheng Influenza Surveillance Hospitals and the influenza outbreak places were collected and sent to Yancheng center for disease control and prevention (CDC) for virus nucleic acids and virus isolation testing. After validation with serological tests, we selected twenty strains of influenza A H3N2 virus isolates to amplify their HA1 and NA genes through reverse transcription polymerase chain reaction (RT-PCR) assay. Results Basically, the clustering relationships and the branche patterns between HA1 and NA genes from the 20 Yancheng A/H3N2 virus strains were similar. The evolutionary distance of two Yancheng isolates(A/Jiangsu-YC/1474/2015 and A/Jiangsu-YC/1725/2015) with the two vaccine strains (A/Switzerland/9715293/2013 and A/Hongkong/4801/2014) were relatively close, however, the other 18 Yancheng isolates were clustered together with many recent domestic strains, which were far from the two vaccine strains (A/Switzerland/9715293/2013 and A/Hongkong/4801/2014). Because the antigen epitopes, receptor binding sites and glycosylation sites in the HA1 genes coding region of Yancheng isolates mutated at a certain degree, vaccine strain A/Switzerland/9715293/2013 was estimated to be less effective than the vaccine strain A/Hongkong/4801/2014 in protecting the influenza infection in Yancheng City from 2015 to 2017. About the catalytic residues and drug resistant sites of NA genes, all 20 isolates of Yancheng H3N2 influenza virus did not change. Conclusions Our results indicated that the HA1 and NA genes of influenza A/H3N2 viruses circulated in Yancheng City from 2015 to 2017 are changing gradually. The accumulation of these mutations would result in antigenic drift of influenza A/H3N2 viruses and increase the mismatch of the IFV field stains with the available vaccine strains, which might reduce the protective effect of flu vaccine.
Surveillance of pathogens in febrile respiratory syndrome in Gansu Province from 2010 to 2015
CHEN Guo-qing, LI Chun-xiang, SHAO Rong-biao, WANG Yao, LI Feng, XU Shi-lin, LI Chang-cheng
2018, 22(9): 908-911. doi: 10.16462/j.cnki.zhjbkz.2018.09.009
Abstract(573) PDF(39)
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Objective To investigate the pathogenic features and change rules of dominant pathogens of febrile respiratory syndrome in Gansu Province from 2010 to 2015, so as to provide the basis for targeted prevention and control. Methods Data was analyzed using observational epidemiology to detect pathogenic infection mode and seasonal change rules of main pathogens of febrile respiratory syndrome. Results Detection-positive rate increased year by year.In gene-ral,the positive rate of cases over 40 years old was higher than that of young people.Viruses with top two positive rates were influenza and rhinovirus, while streptococcus pneumoniae and haemophilus influenzae were the most frequently detected bacteria. The four pathogens were listed steadily in every year. The mixed infection was mainly caused by bacteria combined with virus, and the most common was streptococcus pneumoniae with other pathogens. The monthly distribution features of the four main pathogens above were explored in each year from 2010 to 2015. Influenza was found mainly from November to next February, while also occurred on May, August and September with high incidence. Rhinovirus occurred intensively from August to October, but were also discovered on May and July in 2011 with epidemic peak. Haemophilus influenzae distributed from August to October mostly, whereas streptococcus pneumoniae was mainly revealed in February, August, October and November, while showing high rate in April and May in 2015. Conclusions Different pathogens of febrile respiratory syndrome have their respective seasonal characteristics in Gansu Province from 2010 to 2015. Obvious seasonality patterns of influenza and rhinovirus were observed, but not evident in streptococcus pneumoniae and haemophilus influenzae.
Analysis of the risk factors and pathogenic bacteria distribution of ventilator-associated pneumonia
YANG Mei, MENG Lei, NIU Li-xia, JIANG Xiao-juan, ZHU Wan-qi, LI Xue-chao
2018, 22(9): 912-915,920. doi: 10.16462/j.cnki.zhjbkz.2018.09.010
Abstract(305) PDF(39)
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Objective To analyze pathogenic bacteria distribution and risk factors of ventilator-associated pneumonia(VAP) in patients,who were treated with mechanical ventilation in the First Affiliated Hospital of Anhui Medical University from September 2015 to August 2016, so as to provide the basis of the early prevention and control of ventilator associated pneumonia. Methods A retrospective analysis was conducted among the patients who were treated with mechanical ventilation in the First Affiliated Hospital of Anhui Medical University from September 1, 2015 to August 31, 2016. The pathogenic bacteria distribution and drug resistance rate were studied. Results A total of 751 patients were treated with mechanical ventilation and 303 strains of pathogenic bacteria were isolated. Most of bacteria samples were obtained from sputum (81.85%), blood (6.93%) and urine (2.64%).Gram-negative bacteria, gram-positive bacteria and fungi accounted for 84.61%, 6.93% and 8.91%, respectively. According to the result of drug susceptibility tests, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli were four main types of gram-negative bacteria, and the main type of gram-positive bacteria was Staphylococcus aureus. The risk factors of VAP included patients' indwelling gastric tube, more than three types of antibiotics application, extension of duration of mechanical ventilation and ICU length of stay. Conclusions Gram-negative bacteria accounted for the largest proportion of pathogenic bacteria in patients treated with ventilator. For the purpose of instructing antibiotics selection in clinical practice, it is necessary to explore the rate of drug resistance and other risk factors.
Analysis on the mortality of chronic airway diseases in rural area of Zhangwu and Fengcheng, Liaoning Province in 2016
XU Yu-fei, FAN Xiao-yun, JIANG Xue-qin, ZHU Ying-ying, LIU Bo, LIANG Ya-xue
2018, 22(9): 916-920. doi: 10.16462/j.cnki.zhjbkz.2018.09.011
Abstract(365) PDF(33)
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Objective To understand the death characteristics of chronic airway diseases in Zhangwu and Fengcheng rural areas of Liaoning Province, so as to provide corresponding prevention and control strategies for preventing and treating chronic airway diseases. Methods The death data and total population data of all death caused in Zhangwu and Fengcheng area of Liaoning Province in 2016 were collected. Statistical analysis was conducted by SPSS 20.0 and SAS 9.3 to calculate the order of death, mortality of chronic airway disease, standardized mortality and mortality with age. Results In 2016, the mortality and standardized mortality rates of chronic airway diseases in rural areas of Zhangwu and Fengcheng were 33.16/100 000 and 22.96/100 000, respectively. The standardized mortality rate of female chronic airway disease (23.89/100 000) was greater than that of males (22.07/100 000), and the difference was statistically significant(χ2=480.62,P<0.001);The standardized mortality rate of chronic airway disease in Zhangwu was higher than that in Fengcheng, and the difference was statistically significant(χ2=57 771.18,P<0.001); The number of deaths from chronic airway disease in winter and spring (196 people) was more than that in summer and autumn (127 people). The mortality and standardized mortality rates of chronic airway diseases increased with age(Z1=30.13,Z2=1 189.96,all P<0.05). Conclusions Chronic airway disease is an important disease that causes death in Zhangwu and Fengcheng, Liaoning Province. The characteristics of death have differences in sex, age, region and season, etc. A series of targeted measures should be taken to reduce the mortality of chronic airway disease and to reduce the harm to people.
Interactive effect of age and triglyceride on elderly patients with impaired fasting glucose
TIAN Pei-ru, LI Juan, AI Cong, LIU Xiao-bing, SUN Qiu-hong
2018, 22(9): 921-924. doi: 10.16462/j.cnki.zhjbkz.2018.09.012
Abstract(589) PDF(33)
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Objective To investigate the relationship between age and triglyceride and the effect of their interaction on elderly patients with impaired fasting glucose (IFG). Methods From July to November 2012, 3 492 people aged ≥ 45 years old were enrolled in the physical examination population in the Affiliated of Guilin Medical College. A total of 378 patients with IFG were selected and included in the case group, whereas 374 gender-and age-matched subjects who had normal glucose were included in the control group. The metabolic characteristics of the two groups were compared and analysed. Logistic regression model was used to study the independent effects of risk factors, and the interaction between risk factors was analyzed by additive model and multiplicative model. Results The levels of systolic blood pressure, diastolic blood pressure, body mass index, fasting blood glucose, uric acid, triglyceride, total cholesterol, low density lipoprotein-cholesterol in IFG patients were higher than those in control group, while high density lipoprotein-cholesterol decreased in patients with IFG, the difference was statistically significant(all P<0.05). After adjusting some confounding factors, multivariate Logistic regression analysis showed that people aged ≥ 60 years and with high triglyceride had a 3.513 times higher risk of IFG than those aged <60 years and with normal triglyceride(OR=3.513, 95% CI:2.360-5.230). Interaction analysis of risk factors for IFG elderly showed that there was no multiplicative interaction between age ≥ 60 years and high triglycerides, but with additive interaction, the relative excess risk due to interaction (RERI) was 0.91, the attributable proportion due to interaction (AP) was 25.90% and the synergy index (S) was 1.57. Conclusions There are several metabolic syndromes in individuals with IFG. The positive interaction between advanced age and triglyceride are among the important risk factors for IFG patients, both of which can significantly increase the risk of illness.
Study on growth mixture model of different latent classes of elderly with mild cognitive impairment
YAO Shuang, XIE Meng-ting, ZOU Di-sha, JIANG Ren-mei
2018, 22(9): 925-928. doi: 10.16462/j.cnki.zhjbkz.2018.09.013
Abstract(650) PDF(59)
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Objective To explore the application of the growth mixed model of identifying the latent classes of the elderly people with mild cognitive impairment and identifying the cognitive trajectory of different classes. Methods The growth mixed model (GMM) was constructed by using the follow-up data of the elderly with mild cognitive impairment over the age of 65. Bayesian information criterion(BIC) and the posterior probability were used to determine the number of latent classes and to conduct model evaluation, respectively. Results The elderly with mild cognitive impairment presented three different cognitive trajectories.The initial cognitive function of class 1 was low and decreased rapidly in the short time,and then rebounded in the middle, finally descended to a certain degree and tended to be slow, which was called the "high risk population of dementia", accounted for 4.46% of the total population. Class 2 had a lower cognitive function and a sharp decline in cognitive ability with age, which was called "low risk population of dementia", accounted for 33.28% of the population. Class 3 had higher cognitive function, and the cognitive function decreased slowly with age, which was called "normal aging population", accounted for 62.26% of the total population. Conclusions The study reveals the heterogeneity of the cognitive development trajectory in the elderly population with mild cognitive impairment, which helps health promotion personnel develop interventions for high-risk groups early to reduce the incidence of Alzheimer's disease.
Association of lnc5150 gene polymorphisms with systemic lupus erythematosus
WANG Zhi-xin, HAN Hong-juan, LIU Long
2018, 22(9): 929-932,947. doi: 10.16462/j.cnki.zhjbkz.2018.09.014
Abstract(601) PDF(36)
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Objective To explore the gene polymorphisms of lnc5150 (ENST00000425150) in association with systemic lupus erythematosus (SLE) in a HAN population. Methods A case-control study was performed by recruiting 658 SLE cases and 843 healthy controls. Two lnc5150 single nucleotide polymorphisms (SNPs) (rs144047453, rs141561256) were genotyped using TaqMan genotyping assays on Fluidigm 192.24 system. The distribution of genotype and allele frequencies of two SNPs were detected, besides those, the genotype effects of dominant and recessive models were also analysed. As well, the association between SNPs and clinical manifestations in SLE patients were analysed. Results No significant differences were detected for the distribution of allele and genotype, and we failed to find any significant results about dominant and recessive models of two SNPs (all P>0.05). However, further analysis in SLE patients revealed that the AA genotypes and A allele of the lnc5150 rs141561256 polymorphism were nominally significantly higher in SLE patients with lupus nephritis (LN) (all P<0.05). Conclusions Lnc5150 SNPs are not associated with genetic susceptibility to SLE, but they might contribute to some clinical phenotype of SLE.
Study on the correlation and interaction effect between serum procalcitonin, D-dimer and lung cancer
WANG Jie-bing, PAN Hai-feng, YE Dong-qing
2018, 22(9): 933-937. doi: 10.16462/j.cnki.zhjbkz.2018.09.015
Abstract(425) PDF(32)
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Objective To investigate the relationship between procalcitonin (PCT), serum D-dimer and lung cancer. Methods A total of 166 patients with lung cancer in the last two years and 166 concurrent healthy people or patients without lung diseases were selected. Spearman rank correlation, dose-response relationship of Logistic regression and interaction effect were used to study the correlations between PCT, D-dimer and lung cancer. Results The age, PCT, carcinoembryonic antigen (CEA) and D-dimer were correlated with lung cancer (rs=0.289, 0.262, 0.387 and 0.161). Age (≥ 60 years) (OR=2.53, 95% CI:1.28-5.00, P=0.008), PCT abnormalities (OR=2.10, 95% CI:1.07-4.14, P=0.032), CEA abnormalities (OR=11.68, 95% CI:4.57-29.82, P=0.001) and D-dimer abnormalities (OR=1.43, 95% CI:1.15-1.68, P=0.001) were influencing factors of lung cancer. With the increasing of PCT and D-dimer levels, the risk of lung cancer were increasing, which showed a positive dose-response relationship (all P<0.05). PCT and D-dimer had a positive additive model interaction with lung cancer, and at the same time increased the risk of lung cancer (interaction index=2.16, 95% CI:1.08 -5.43; interaction the role of excess relative risk=1.29, 95% CI 0.68-2.71; interaction attribution ratio=0.75, 95% CI:0.37-1.42). Conclusions High PCT and D-dimer are risk factors of lung cancer, and there is a significant dose-response relationship between them. Meanwhile,there is a positive additive interaction effect between PCT and D-dimer in an additive model,the risk of lung cancer will increase significantly when both of them are at an abnormal high level.
Expression and clinicopathological correlation of Keap l-Nrf 2 signal pathway protein in non-small cell lung cancer
LU Yong-bin, TENG Yong-jun, WEI Ning, CHANG Rui-xia, XU Xin-ni, YAO Jia, CHENG Ning
2018, 22(9): 938-942. doi: 10.16462/j.cnki.zhjbkz.2018.09.016
Abstract(544) PDF(38)
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Objective To observe the expression of kelch-like ECH-associated protein 1 (Keap1) and nuclear factor E2 related factors (Nrf2) protein in non-small cell lung cancer (NSCLC), and to explore its clinical association with NSCLC. Methods Keapl, Nrf2 protein expressions in 92 cases of NSCLC and its adjacent tissues(≥ 10 cm) were detected by immunohistochemical streptavidin-perosidase(SP) method and protein immunoblot method, and their correlation with NSCLC tumor tissue type, tumor-node-metastasis(TNM) stage, the degree of differentiation, lymph node metastasis were analyzed. Results The expression of Keapl protein and Nrf2 protein in NSCLC were increased by immunehistochemical staining. The protein optical density (OD) values of the adjacent tissues were (0.327±0.053) and (0.313±0.062) respectively, and two proteins in the NSCLC tissues were significantly elevated, and the lower the differentiation degree of NSCLC, the more obvious the increase of the two protein OD values. Moreover, the higher of NSCLC tumor T stage, the positive expression of Keap1 and Nrf2 protein increased. The expression of Nrf2 protein and Keapl protein in NSCLC tissues was elevated and correlated with the degree of differentiation of tumor tissues. Conclusions The high expression expression of Nrf2 protein and Keapl protein in NSCLC has some significance in judging the malignancy of tumor.
Water level changes caused from the Three Gorges Dam impact on the breeding and distribution of Oncomelania snails in the marshland of Chenqiaozhou, Hexian County, Anhui Province
ZHU Xue-ying, MA Dong-chun, WANG Bao-ming, ZHU Feng, CAO Wei, YIN Tong-xin, CHEN Xiao-yu
2018, 22(9): 943-947. doi: 10.16462/j.cnki.zhjbkz.2018.09.017
Abstract(234) PDF(39)
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Objective To explore the effect of water level changes caused by the Three Gorges Dam on the breeding and distribution of Oncomelania snails in the marshland of Chenqiaozhou of Hexian County, Anhui Province. Methods From 1990 to 2016, the daily average water level of the Yangtze River in Chenqiaozhou area, the area and density of Oncomelania snails, and data of snail control with molluscicide in the marshland of Chenqiaozhou were collected, field study was also conducted to understand the development and utilization of the marshland. By comparing the changes of various indicators before and after the operation of the project, this study tried to analyze the relationship between water lever and utilization of marshland as well as breeding of snails. Results After the completion of the Three Gorges Project, the water level of the Yangtze River in Chenqiaozhou was generally declined, the median value of annual flooding days of the marshland was reduced from 59 d to 21 d (Z=2.440, P=0.015), the reclamation area had been increased from 0.95 km2 to 4.55 km2, which had reached 85.0% of the total area of marshland. The coverage rate for snail controlled with molluscicide was significantly reduced, and the median value of annual coverage rate was reduced from 33.0% to 0.0% (Z=4.116, P<0.001).The snail area decreased slowly, and median value of annul snail area was reduced from 317.6 hm2 to 264.6 hm2 (Z=1.744, P=0.081). The average density of live snails decreased rapidly, and median value of annul snail density was reduced from 0.84 number/0.11 m2 to 0.27 number/0.11 m2 (Z=3.779, P<0.001). Conclusions After completion of the Three Gorges Project, the change of water level in the lower reaches of the Yangtze River in Anhui area and its influence on the exploitation and utilization of the marshland affect negatively on the breeding and spreading of snails, playing a positive role in the control of schistosomiasis.
Study on the levels and risk factors of neonatal vitamin D in Yangzhou
ZHANG Guang-ming, MA Shi-chuan, CAO Zhi-guo, WANG Yue, ZHANG Shi-qing, WANG Tian-ping, WANG Xue-long
2018, 22(9): 948-952. doi: 10.16462/j.cnki.zhjbkz.2018.09.018
Abstract(348) PDF(26)
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Objective To investigate vitamin D (VD) levels of newborns in Yangzhou, and examine the risk factors of neonatal VD deficiency. Methods The pregnant women who set up health card in Maternal and Child Health Hospital of Yangzhou from May 2014 to May 2015 during the first trimester were selected as the initial study subjects. According to inclusion and exclusion criterion, 3 913 healthy singleton live birth newborns were enrolled in the present study, and related information of pregnant women and newborns were collected with a self-designed questionnaire. The VD concentration of pregnant women and newborns were examined by enzyme-linked immunosorbent assay. The distribution characteristics and risk factors of neonatal VD were described and analyzed. Results The levels of neonatal VD were (28.79±8.37) nmol/L in Yangzhou. The prevalence of sufficiency, insufficiency, and deficiency were 2.2%, 11.7%, and 86.1%, respectively. Multivariate logistic regression model analysis showed that VD deficiency (OR=3.16, 95%CI:2.00-5.00, P<0.001) and VD insufficiency (OR=1.67, 95%CI:1.04-2.67, P=0.033) in the second trimester of pregnancy, VD deficiency (OR=8.64, 95%CI:5.64-13.24, P<0.001) and VD insufficiency (OR=1.63, 95%CI:1.07-2.49, P=0.024) in the third trimester of pregnancy, and fetal delivery in winter-spring (OR=1.49, 95%CI:1.13-1.97, P=0.004) were risk factors of neonatal VD deficiency. Conclusions VD deficiency of newborns were common in Yangzhou. The VD status of pregnant women in the second and third trimesters of pregnancy and the season of fetal delivery were associated with neonatal VD deficiency.
The relationship between social support and self-management efficacy in patients with primary liver cancer after surgery
SUN Lei, CHEN Yao, XU Yang, DING Yu-qin, CHENG Wen-guo, SHI Chang-cheng
2018, 22(9): 953-956. doi: 10.16462/j.cnki.zhjbkz.2018.09.019
Abstract(471) PDF(26)
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Objective To evaluate the current status of social support and self-management efficacy in patients with primary liver cancer (PLC) after surgery, and analyze the effect of social support on self-management efficacy. Methods Patients with PLC underwent surgery at the First Affiliated Hospital of Anhui Medical University between January 2015 and April 2017 were surveyed with questionnaires. Data was collected by social support rating scale (SSRS) and strategies used by people to promote health (SUPPH). Results The average score of SSRS and SUPPH were (35.86±6.73) and (94.11±20.02) respectively. SSRS had a positive correlation with SUPPH (all P<0.05). Multivariate linear regression analysis showed that the subjective support, objective support and support utilization were related to the self-management efficacy of PLC patients significantly (all P<0.05). According to the standardized regression coefficient, the effect intensity of each independent variable on self-management efficacy was ranked as follows:subjective support, objective support, and support utilization. Conclusions The social support and self-management efficacy in patients with PLC after surgery are both at a moderate level. Good social support can help to improve sense of self-management. These data also strongly suggested that health care personnel should help patients to establish an effective social support system, thereby increasing self-management efficacy.
Forecast of incidence trend of influenza-like illness by the ARIMA model based on R
ZHANG Ling, WANG Wei-li, HU Shao-hua
2018, 22(9): 957-960. doi: 10.16462/j.cnki.zhjbkz.2018.09.020
Abstract(692) PDF(84)
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Objective To analyze the feasibility of predicting the incidence trend of influenza-like illness (ILI) by using the autoregressive integrated moving average (ARIMA) model, which provided technical support for influenza prevention and control. Methods The daily ILI monitoring data reported by the hospital from the 1st week of 2013 to the 26th week of 2017 were collected, a time series analysis was conducted and a prediction model was established with R. Results The overall consultation rate of influenza like illness (ILI%) monitoring data showed a downward trend and had obvious seasonal character. The best predictive model was ARIMA (0,1,1)(0,1,1)52, of which the residual error Box-Pierce test result was χ2=7.07 (P=0.315), χ2=17.22 (P=0.142). The residual error was a white noise sequence, and the actual values of the prediction results were within the 95% confidence interval (95%CI) of the predicted value. Conclusion The ARIMA model can be available for the prediction of short-term incidence trend of ILI in this hospital.
Application of decision tree in the analysis and prediction of risk factors of severe hand, foot and mouth disease combined with meningocephalitis
WANG Chen, GUO Qian, ZHOU Luo-jing
2018, 22(9): 961-964. doi: 10.16462/j.cnki.zhjbkz.2018.09.021
Abstract(443) PDF(31)
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Objective To explore the risk factors in the severity progress of children's hand-foot-mouth disease (HFMD) combined with meningocephalitis by the model of C5.0 mixing with the Logistic regression (C5.0 combined models for short). Methods The method of cluster sampling was used to recruit the 324 cases of HFMD children in Zhengzhou Children's Hospital from April 2015 to July 2017. SPSS 21.0 was used to conduct the analysis of Logistic regression. SPSS Modeler 18.0 was used to establish the C5.0 model, SPSS Modeler 18.0 was used to establish the C5.0 combined models based on single Logistic regression analysis. The three models were compared by the differences of the results. Results The results of the three models were as follows:The C5.0 combined models showed heart rate above 140 time per minute, elevated blood sugar, shake of hands and feet and dysphoria. The C5.0 model showed heart rate above 140 time per minute, disorder of consciousness, elevated blood sugar, shake of hands and feet and vomiting. The Logistic regression model showed heart rate above 140 time per minute, shake of hands and feet, elevated blood sugar, vomiting, dysphoria and the ratio of neutrophils. The sensitivity, specificity, Youden index and the area under the ROC of the three models were as follows:the C5.0 combined models were 95.7%, 94.2%, 0.90, 0.946, the model of C5.0 were 80.7%, 88.3%, 0.69 and 0.845 respectively, the Logistic regression model were 98.0%, 70.0%, 0.68 and 0.840 respectively. Conclusions The model of C5.0 combined with the single Logistic regression is better than the C5.0 model and the Logistic regression model which are used to predict the risk factors in the severity progress of HFMD combined with meningocephalitis.
Investigation on acceptance of HPV vaccination and its determinants among college students in Guangzhou City
MA Xiao-mei, YAN Guo-li, DUAN Guang-cai, REN Zhi-hua, XU Xue-qin, SUN Chun-yang
2018, 22(9): 965-967,971. doi: 10.16462/j.cnki.zhjbkz.2018.09.022
Abstract(1356) PDF(158)
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Analysis and prediction of incidence of varicella in Yuyao City from 2011 to 2017
ZHANG Jie, ZHANG Jia-yi, PANG Min-hui
2018, 22(9): 968-971. doi: 10.16462/j.cnki.zhjbkz.2018.09.023
Abstract(318) PDF(22)
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Mosquito breeding container and relationship between container index and meteorological factors in Guangzhou from 2010 to 2016
SHI Shan-shan, HU Bi-bo, ZHENG Yong
2018, 22(9): 972-974. doi: 10.16462/j.cnki.zhjbkz.2018.09.024
Abstract(333) PDF(29)
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Epidemiological characteristics and breakthrough cases of 32 varicella outbreaks in 2017, Jiangsu Province
DU Xiao-yun, LI Xiao-ning, YANG Zhi-cong
2018, 22(9): 975-977. doi: 10.16462/j.cnki.zhjbkz.2018.09.025
Abstract(359) PDF(40)
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A study on influencing factors of vaginal birth after cesarean
ZHANG Lei, LIU Yuan-bao, SUN Xiang, XU Yan, WANG Zhi-guo
2018, 22(9): 978-980. doi: 10.16462/j.cnki.zhjbkz.2018.09.026
Abstract(361) PDF(28)
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LI Yan, ZHOU Ping, WANG Fen
2018, 22(9): 981-981.
Abstract(305) PDF(7)
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