Study on transition levels of maternal neutralizing antibodies against enterovirus 71 and coxsackievirus A16 in infants in Guangzhou

Objective To explore the transition levels of maternal neutralizing antibodies against enterovirus 71 (EV71) and coxsackievirus A16(CoxA16) in infants in Guangzhou, and to provide the scientific evidence for establishing corresponding immunization course.Methods Prenatal women who took a delivery in Liwan Maternal and Child Health Hospital from July 2013 to April 2014 and their infants were included in the study.Method of micro-dose cytopathogenic effect was used to measure neutralizing antibodies against EV71 and CoxA16, respectively. Seroepidemiological analysis was also conducted.Results The mothers' seropositive rates and geometric mean reciprocal titers(GMRTs) of EV71 and CoxA16 antibodies were 83.98%, 88.95% and 25.42, 27.00, respectively; the newborns' seropositive rates and GMRTs of EV71 and CoxA16 antibodies were 74.03%, 71.82% and 20.50, 16.48, respectively. The EV71 and CoxA16 antibody titers of newborns were positively associated with those of mothers(r_EV71=0.70,P<0.001;r_CoxA16=0.75,P<0.001), which decreased with the increased ages (χ_EV71²=100.23,P<0.001;χ_CoxA16²=112.24,P<0.001).Conclusions The vaccine should be vaccinated in 6 months of age. It is suggested that the women of childbearing age should be inoculated with hand, foot and mouth disease vaccine to reduce the incidence rate of infants who are under 6 months of age.