A systematic review and Meta-analysis on the relationship between microRNAs and prognosis in diffuse large B-cell lymphoma

Objective To comprehensively analyze the prognostic value of different microRNAs (miRs) in diffuse large B-cell lymphoma(DLBCL).Methods A computerized retrieval was carried out by using Wanfang data,VIP databases,CNKI, PubMed and Embase databases to collect the relevant literatures published from January 2007 to July 2007.By screening, Meta-analysis was performed with Stata 12.0 software.Results Thirty literatures comprised 2 574 cases were included. Comprehensive analysis revealed that decreased expression of miR-21 was associated with shorter relapse-free survival(RFS)in DLBCL(HR=0.61,95% CI:0.40-0.94, P=0.024). Increased expression of miR-155 was associated with shorter progression-free survival(PFS)(HR=2.50,95% CI:1.54-4.06, P<0.001). Increased expression of miR-222 was associated with shorter PFS(HR=2.33,95% CI:1.53-3.57, P<0.001).Conclusions According to the results, it can be concluded that miRs especially miR-21,miR-155 and miR-222 are valuable prognostic predictors in DLBCL of recurrence free survival and progression free survival period.