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CN 34-1304/R ISSN 1674-3679

2018 Vol. 22, No. 7

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Effect of socio-psycho-behavioral factors on male fertility
YANG Huan, CAO Jia
2018, 22(7): 653-655. doi: 10.16462/j.cnki.zhjbkz.2018.07.001
Abstract(591) PDF(48)
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Increasing interests have been paid to socio-psycho-behavioral factors, which could cause declined semen quality, abnormal levels of sex hormones, decreased pregnancy rate, adverse pregnancy outcomes or even infertility. We thereby present those protruding and public concerned factors which may affect male reproduction, as well as its research advance.
Mortality of road traffic injury among children aged 0-14 years by provinces in China from 1990 to 2015
YE Peng-peng, JIN Ye, DUAN Lei-lei
2018, 22(7): 656-662. doi: 10.16462/j.cnki.zhjbkz.2018.07.002
Abstract(636) PDF(81)
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Objective To understand the current status and trend of the mortality of road traffic injury among children aged 0-14 years in different gender, age groups and provinces in China from 1990 to 2015, so as to make clusters and provide prevention and control strategies. Methods Data of road traffic injury mortality in China from 1990 to 2015 were collected from global disease burden 2015 to explore current status of road traffic injury among children aged 0-14 years and to calculate the relative change and the annual percent changes from 1990 to 2015. The potential number of clusters of provinces was analyzed by adopting k-median cluster analysis. Results In 2015, the mortality rate of road traffic injury in boys aged 0-14 years was higher than that in girls at the same age range. The mortality rate in the children aged less than 5 years old was higher than that in older age groups. From 1990 to 2015, there was a significant decline in the mortality rate of road traffic injury among children aged 0-14 years in different gender, age groups and provinces. The extent of decline was comparable between boys and girls, but higher in younger children. The highest and lowest extent of decline was observed in Hong Kong Special Administrative Region and Anhui Province respectively. There were four different clusters for all provinces according to the current status and trend of road traffic injury among children aged 0-14 years. Conclusions There was a significant decline in the mortality rate of road traffic injury among children aged 0-14 years in different gender, age groups and provinces in China from 1990 to 2015. However, road traffic injury is still a severe threaten for children in China. More attention should be paid on young boys in some provinces when conducting child road traffic injury intervention and control programs.
Impact of maternal pre-pregnant body mass index, gestational weight gain and pregnant anemia on SGA in Zhuang Region
SHAO Yan-tao, HUANG Dong-ping, LIU Shun, HUANG Qian, LU Mei-ju, GUO Xue-feng, CHEN Jie-hua, QIU Xiao-qiang
2018, 22(7): 663-666. doi: 10.16462/j.cnki.zhjbkz.2018.07.003
Abstract(397) PDF(38)
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Objective To analyze the occurrence of small for gestational age infants (SGA) in Zhuang ethnicity region and the effects of pre-pregnant body mass index (BMI), gestational weight gain and pregnant anemia on SGA, to provide rationale to develop better health care for pregnant women. Methods A total of 2 199 pregnant women of single pregnancy were selected as the participants, who received the first prenatal examination during the first 6 to 13 weeks of gestation in Pingguo People's Hospital, Child Health Hospital and Long'an People's Hospital from January to December 2016, data of the general conditions of pregnant women, regular prenatal examination records, the pregnancy outcomes etc were collected. t-test, χ2 test and Logistic regression model were used for statistical analysis. Results A total of 327 infants were SGA, and the incidence of SGA was 14.87%. After adjusting the confounding factors, compared to the normal pre-pregnant BMI group, the pre-pregnant BMI <18.5 kg/m2 group showed increased risk of SGA (OR=2.09, 95% CI:1.59-2.75, P<0.001), compared to the normal gestational weight gain group, women with insufficient gestational weight gain had increased risk of SGA (OR=2.19, 95% CI:1.67-2.86, P<0.001) among their infants. There was no significant difference in the risk of pregnant anemia on SGA (all P> 0.05). Conclusion Pre-pregnant BMI<18.5 kg/m2, insufficient gestational weight gain are risk factors for SGA in Zhuang ethnicity region.
A case-control study on influencing factors of birth defects in children under 5 years old in Jilin Province
ZHANG Li-ming, ZHANG Xiu-min, MA Yue
2018, 22(7): 667-671. doi: 10.16462/j.cnki.zhjbkz.2018.07.004
Abstract(376) PDF(44)
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Objective To investigate the risk factors of birth defects in children under 5 years of age in Jilin Province, and to provide scientific basis for formulating comprehensive prevention and control strategies for birth defects. Methods Birth defects in the sample survey of children under 5 years of age in Jilin Province were treated as case proup. Normal children were drawn at equal proportion as control group. A case-control study was conducted with 379 cases and 379 controls. Data was analyzed for descriptive study. Univariate Logistic regression and multivariate Logistic regression were analyzed with SPSS 21.0 software. Results Multivariate Logistic regression analysis showed that mother's occupation was worker(OR=4.328, 95% CI:1.416-13.227, P=0.010)and houseworker(OR=2.602, 95% CI:1.311-5.163, P=0.006), mother was sick before and during pregnancy (OR=4.074, 95% CI:1.413-11.746, P=0.009), mother had a bad pregnancy outcome before the defect child (OR=2.640, 95% CI:1.696-4.110, P<0.001), mother had a fever(>38℃) in the early weeks of pregnancy(OR=8.924, 95% CI:2.856-27.889, P<0.001)were risk factors of birth defects. Mother took low dose of folic acid supplements before pregnancy, and prenatal down syndrome screening were protective factors (all P<0.05). Conclusions Preconception and early pregnancy intervention, avoiding risk factors and supplementation of folic acid are important to prevent birth defects.
The relationship between fine particulate matter and hospital outpatients with pediatric respiratory diseases in Shijiazhuang City
DING Ya-ping, YU Ming-xing, HAO Hai-yan, MA Kai-li, LIU Yi-gang, ZHAO Chun-ni, WANG Tong
2018, 22(7): 672-676. doi: 10.16462/j.cnki.zhjbkz.2018.07.005
Abstract(422) PDF(46)
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Objective To analyze the relationship between fine particulate matter and hospital daily outpatients with pediatric respiratory diseases in Shijiazhuang. Methods The data of meteorology, air pollution and the daily outpatients with pediatric respiratory diseases were collected during 2014-2016 in Shijiazhuang. Generalized additive model (GAM) extended Poisson distribution was used to examine the relationship between fine particulate matter and hospital outpatients with pediatric respiratory diseases in Shijiazhuang. According to the exposure-response relationship curve, piecewise linear regression was used for risk analysis. Results During the study period, the average annual concentration of PM2.5 in Shijiazhuang was 104.93 μg/m3 and the average number of daily hospital outpatients was 690 to the pediatric respiratory diseases. The exposure-response relationship suggested a nonlinear between PM2.5 and daily hospital outpatient visits. A larger increase in daily hospital outpatient visits was observed at lower concentration of PM2.5. An increase of 10 μg/m3 of PM2.5 (lag1)was significantly related to hospital outpatients with respiratory diseases and could increase the excess risk of 0.26%(0.14%-0.38%). By moving average concentration analysis, there was a cumulative lag effect between PM2.5 concentrations pediatric respiratory visits. The highest influence between PM2.5 and accumulative effects for pediatric respiratory diseases visits was occurred in lag 0-7. The analysis of multiple pollutants model showed that the effect of PM2.5 on the outpatient respiratory diseases decreased when only SO2 was introduced, and it was statistically significant. But there was no statistical significance when introducing other pollutants(all P>0.05). Conclusion The PM2.5 in Shijiazhuang may lead to the increase in hospital outpatients with pediatric respiratory diseases.
Genome-wide differential gene expression in children and adults exposed to air pollution
SUN Na, LIU Qi-ling, ZHANG Rong-qiang, ZHANG Fan, LI Xing-hui, LI Xiang-wen
2018, 22(7): 677-681,686. doi: 10.16462/j.cnki.zhjbkz.2018.07.006
Abstract(453) PDF(37)
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Objective To analyze the effect of air pollutants on gene expression profiles of peripheral blood in adults and children by bioinformatics research methods, so as to provide theoretical reference for future prevention, diagnosis and treatment. Methods A group of peripheral blood microarray data from children and adults exposed to different air pollution were downloaded from the gene expression omnibus (GEO) database. The data were analyzed by QOE, GenClip, GATHER and other data analysis software to identify the gene expression profiles, protein-protein interaction networks, molecular biology process and gene function, thereby to search key genes by which air pollution affects adults and children. Results In the same exposure source, key difference genes of the children were different from those of the adults'. The identified key genes of latter were mainly related to cell proliferation, chromosome modification, DNA metabolism and chromosome organization, while the genes of the former were mainly related to platelet activation, cell signal conduction, and organic physiological process. Further analysis revealed that FIGNL1, TUBB1, TPST1 and SAMHD1 genes were common genes in adults and children, and these genes were mainly related to tumor induction and inhibition. Conclusions Alteration in gene expression profile varies in adults and children who are exposed to the different air pollution levels. In the same exposure source, the difference genes between children and adults are also different. These common different genes are mainly related to the induction and inhibition of tumor.
A survey of sleep quality among college students from eight universities of Chinese medicine in China
LI Bai-kun, ZHAN Yu-can, LI Jing, JIANG Rui-xuan, ZHU Ji-min
2018, 22(7): 682-686. doi: 10.16462/j.cnki.zhjbkz.2018.07.007
Abstract(489) PDF(86)
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Objective To investigate the sleep quality of college students from eight universities of Chinese medicine and analyze the possible influencing factors. Methods A stratified cluster sampling method was used to obtain 7 142 college students from 8 universities of traditional Chinese medicine in four regions of China. The Pittsburgh sleep quality index (PSQI) and a self-designed questionnaire were used to carry out a cross-sectional survey. Results Totally 6 534 valid questionnaires were retrieved, boys 1 778 (27.21%), girls 4 756 (72.79%); the mean age was (20.32±1.23) years. The mean score of PSQI was (4.58±2.30), detection rate of insomnia (PSQI ≥ 8) was 10.33%. The score of PSQI of students from cities (4.36±2.32) was better than those from villages and towns (4.64±2.29, t=-3.909, P<0.001). The score of PSQI of students who belonged to extroversion (4.50±2.38) and intermedius type (4.54±2.25) was better than those who belonged to introversion (4.78±2.35, F=6.481, P=0.002). The score of PSQI of students with normal weight(4.52±2.22) was better than those who were underweight (4.64±2.38), overweight (4.89±2.60) or obesity (5.03±2.60, F=5.892, P=0.001). There was no significant difference in PSQI score between different genders(t=-0.005, P=0.996). Multiple regression analysis showed that there were twelve factors which may influence college students' sleep quality like index of pressure, life satisfaction and regular dietary. Conclusions The sleep quality of students from universities of Chinese medicine which was influenced by many factors still needs to be further improved.
Association of peripheral inflammatory factors with cognitive performance in mild cognitive impairment
AN Pei-lin, MA Fei, ZHOU Xuan, ZHAO Jian-gang, SONG Ai-li, LI Qing, HUANG Guo-wei
2018, 22(7): 687-691. doi: 10.16462/j.cnki.zhjbkz.2018.07.008
Abstract(420) PDF(36)
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Objective To explore the association between peripheral inflammatory factor levels and cognitive performance in the older people with mild cognitive impairment population (MCI). Methods A case-control study was performed, consisting of 150 MCI patients and 101 healthy controls.The Wechsler Adult Intelligence Scale was revised in China (WAIS-RC) was used to assess the cognitive function. Serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and amyloid β-protein (Aβ) levels were measured by ELISA and Milliplex Map Cytokine Kit. Results The levels of serum IL-6 and Aβ42 in MCI group were both higher than those in control group (all P<0.05). Multiple linear regression showed there was significant correlation between the increase of Aβ42 level and the decrease of verbal intelligen quotient (VIQ) (β=-0.285, P<0.001). Elevated IL-6 and TNF-α levels were associated with the decrease of performative in telligence quotient (PIQ) and full intelligence quotient (FIQ) (all P<0.05). Conclusions Serum IL-6 and Aβ42 levels are increased in MCI patients. Serum levels of IL-6 and TNF-α could evaluate the performative and general intellectual impairment of MCI, and the level of Aβ42 could be used as an assessment factor of verbal intellectual impairment in MCI.
Study on the correlation between cognitive impairment and mortality risk in Chinese elderly women
LUO Ya-nan, JIN Xin, WANG Zhen-jie, ZHENG Xiao-ying
2018, 22(7): 692-695. doi: 10.16462/j.cnki.zhjbkz.2018.07.009
Abstract(441) PDF(44)
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Objective To explore the correlation between cognitive impairment and mortality risk in Chinese elderly women. Methods Based on data from the Chinese Longitudinal Healthy Longevity Survey (2002-2011), Cox proportional Hazard Model was used to analyze the correlation between cognitive impairment and mortality risk, taking cognitive impairment as dependent variable, adjusting demographic variables (age, sex, residence, ethnic, marriage and education) and healthy variables (activity of daily living, hypertension, stroke and diabetes, as well as optimism and happiness). Results The mortality risk of cognition impaired group was 2.22 times that of control group (HR=2.22, 95% CI:2.08-2.37, P<0.001). After adjusting confounding factors, cognitive impairment was still related with high mortality risk among the whole sample (HR=1.14, 95% CI:1.05-1.22, P=0.001). There was a sex difference in rural areas. The correlation still existed among urban women (HR=1.21, 95% CI:1.08-1.36, P=0.001), the relation among rural women was not significant (HR=1.09, 95% CI:0.99-1.20,P=0.075). Conclusions Cognitive impairment is associated with high mortality risk in elderly women, and has a rural-urban difference. Intervening factors influencing the occurrence and development of cognitive impairment can play an important part in reducing mortality risk of the elderly and improving their health and quality of life.
The eastern-middle-western depression and the determinants among Chinese rural elderly
TAO Hui-wen, ZHANG Xiao, WANG Zhen
2018, 22(7): 696-699. doi: 10.16462/j.cnki.zhjbkz.2018.07.010
Abstract(647) PDF(54)
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Objective To investigate the disparity and determinants of depression of rural elderly among eastern, middle and western regions. Methods China health and retirement longitudinal study dataset of 2013, binary Logistic regression were adopted to analyze determinants of depression among 2 896 rural elderly who were 65 and older. Results The difference of eastern-middle-western depression was statistically significant (χ2=33.63, P<0.001). There were 24.34% depressive elderly from eastern area, 30.11% from middle area and 36.77% from western area. The depression was mainly influenced by gender, marital status, household monthly average expenditure, social activities, drinking, chronical disease and self-rated health (all P<0.05). And having parterns(OR=0.774,95% CI:0.640-0.936), middle monthly household average expenditure(OR=0.797, 95% CI:0.651-0.977), joining in social activities(OR=0.788, 95% CI:0.668-0.930) and drinking(OR=0.789, 95% CI:0.649-0.960) were protective factors of depression, while female(OR=1.736, 95% CI:1.400-2.153), chronical disease(OR=1.328,95% CI:1.091-1.618)and bad self-rated health status (OR=2.924, 95% CI:2.259-3.784) were risk factors. Conclusions Early and effective measures should be taken to prevent and cure depression of rural elderly. And choronical disease need to be prevented to promote rural elderly's health status.
The multiple linear regression analysis on depression and quality of life of leprosy patients
XIONG Ming-zhou, LI Ming, WANG Xiao-hua, SU Ting, ZHENG Dao-cheng, YANG Bin
2018, 22(7): 700-702,707. doi: 10.16462/j.cnki.zhjbkz.2018.07.011
Abstract(530) PDF(54)
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Objective To analyze the correlativity of depression with the dimensions of quality of life (QOL) of leprosy patients. Methods The center epidemiological studies of depression scale (CES-D) and world health organization quality of life questionnaire-brief version (WHOQOL-bref) were used to assess the depression and QOL of leprosy patients in Guangdong Province, and their correlativity was analyzed by the multiple linear regression analysis method. Results A total of 263 participants completed the survey, including 177 males (67.3%) and 86 females (32.7%). Among them, 131 participants (49.8%) presented depression symptoms, and these people got significant lower scores in all the dimensions of QOL than people without depression symptom(all P<0.05). The regression coefficients between depression and overall QOL, physical, psychological, social relationship and environment were -0.340, -0.322, -0.644, -0.424 and 0.244, respectively. All the regression coefficients got statistical significance (all P<0.05), except overall QOL. Conclusions High depression symptom rate has been found in leprosy patients in Guangdong Province, the QOL scores have significant correlations with CES-D score. Multilevel interventions should be taken to prevent the occurrence of depression among leprosy patients.
Combined effects of hypertension and central obesity on the risk of cardio-cerebrovascular diseases
QU Xin-yuan, JI Wen, WANG Xin-ya, JIANG Yan-bo, ZHANG Shao-yan, ZHANG Yong-hong, WANG Cong-ju, ZHANG Ming-zhi
2018, 22(7): 703-707. doi: 10.16462/j.cnki.zhjbkz.2018.07.012
Abstract(540) PDF(64)
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Objective To evaluate the combined effects of hypertension and central obesity on the risk of cardio-cerebrovascular diseases. Methods A total of 9 984 residents from Suzhou New District were recruited as study subjects in our cross-sectional study from March 2016 to April 2016. Demographic data, disease and lifestyle history were collected. Physical and biochemical indicators were examined for all individuals. Logistic regression model was used to analyze the association between central obesity combined with hypertension and cardio-cerebrovascular diseases. Results Among 9 984 participants, 396 people suffered from cardio-cerebrovascular diseases (period prevalence:3.97%), including 243 coronary heart disease patients (period prevalence:2.43%), and 178 stroke patients (period prevalence:1.78%). Compared with normotensives with non-central obesity, in a multivariate adjusted model, the OR and 95% CI of stroke, coronary heart disease and cardio-cerebrovascular diseases for hypertensives with central obesity were 3.10(1.78-5.40), 2.56(1.61-4.07) and 3.06(2.10-4.45), respectively (all P<0.05). Conclusion These results indicate that the coexistence of hypertension and central obesity may increase the risk of cardio-cerebrovascular diseases.
Effect of community comprehensive health management on quality of life in elderly hypertensive patients
WANG Fou, GU Jia-yi, XU Hui, YU Qing, CHAO Jian-qian
2018, 22(7): 708-711,716. doi: 10.16462/j.cnki.zhjbkz.2018.07.013
Abstract(515) PDF(35)
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Objective To explore the changes of blood pressure and quality of life in elderly hypertensive patients in Nanjing under community comprehensive health management. Methods From March to December 2013, 520 elderly hypertensive patients aged over 60 years were recruited from a community hospital in Nanjing, and were divided into the control group and the management group according to the principle of simple random assignment. The management group of elderly patients with hypertension had the special community health management, but the control group of elderly patients with hypertension had no intervention measures. A total of three surveys with questionnaires were conducted at baseline, mid (at the 6 months), and final periods (at the 18 months), and then used the multilevel model to analyze the change of quality of life. Results There were no significant differences in the baseline data between the management group and the control group (all P>0.05). After the 18 months of intervention, when management group compared to control group, the mean reduction of systolic pressure was (4.74±1.69)mm Hg (t=2.801, P=0.006), mean reduction of diastolic pressure was (3.67±1.17)mm Hg (t=3.158, P=0.002). The difference was statistically significant; In addition,the two groups had significant differences in vision situation (Z=-3.142, P=0.002), teeth status (Z=-2.130, P=0.034), sleep status (Z=-3.471, P<0.001), mental status (Z=-2.051, P=0.040) and total score of quality of life (Z=-2.653, P=0.008). All of them in management group was better than that of the control group.The change of score in quality of life of management group was also better than that of the control group. Conclusion Community health management can improve blood pressure control and the quality of life for elderly hypertensive patients.
Association between induced abortion and diabetes among female adults in coastal areas of East China
CHEN Lu-lu, BAN Qian-yun, WU Hong-xu, MA Hai, WANG Xi-sheng, WANG Bin-yan, QIN Xian-hui, ZANG Tong-hua, XU Xi-ping
2018, 22(7): 712-716. doi: 10.16462/j.cnki.zhjbkz.2018.07.014
Abstract(497) PDF(32)
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Objective To test the association between induced abortion and diabetes among female adults in coastal areas of East China. Methods An epidemiological investigation was conducted among female adults in Rongcheng of Shandong Province, from February 2017 to August 2017. Standardized questionnaire and anthropometric measurements were conducted to collect each participant's relevant information. Multivariable Logistic regression models were performed to determine the association between induced abortion and diabetes. Results A total of 44 806 female adults were enrolled in the final analysis. The prevalence of diabetes in those without induced abortion, with once, twice, three times, four and more than four times induced abortion was 16.3%, 17.2%, 18.3%, 18.8% and 20.2%, respectively. Overall, compared with participants without induced abortion, the significantly higher prevalence of diabetes was observed in those with twice induced abortion (OR=1.11, 95% CI:1.02-1.21, P=0.021), three times induced abortion (OR=1.17, 95% CI:1.02-1.34, P=0.027), four and more than four times induced abortion (OR=1.24, 95% CI:1.03-1.50, P=0.026). Conclusion The induced abortion is significantly associated with the prevalence of diabetes in female adults in coastal areas of Eastern China, and the more times of induced abortion, the higher prevalence of diabetes is.
Analysis on psychology status of patients with diabetic retinopathy during preoperative period and its influencing factors
LIU Yong-ling, GAO Jian, YANG Xin-yu
2018, 22(7): 717-720. doi: 10.16462/j.cnki.zhjbkz.2018.07.015
Abstract(460) PDF(57)
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Objective To investigate the psychology status of patients with diabetic retinopathy during preoperative period and its influencing factors. Methods A total of 86 diabetic retinopathy (DR) patients from the First Affiliated Hospital of Anhui Medical University were enrolled in the cross-sectional study, who were investigated by using general information questionnaire, diabetes distress scale (DDS) and self-rating anxiety scale (SAS). Among them, 49 patients underwent vitrectomy, 37 patients underwent vitrectomy and silicone oil filling. T test was used to compare the measurement data between groups, and rank sum test was used to compare the grade data. Logistic regression analysis was used to evaluate influencing factors of anxiety and pain. Results 56 participants with DR suffered psychological pain while the other 31 suffered anxiety. There was significant difference between the two groups in DDS and SAS (all P<0.05). The multifactor analysis showed treatment method (OR=3.116, 95% CI:1.036-9.372, P=0.043) was risk factor of distress. Female (OR=4.376, 95% CI:1.052-18.201, P=0.042), genetic history of the diabetes (OR=7.596, 95% CI:1.788-32.272, P=0.006) and treatment method (OR=12.742, 95% CI:3.609-44.983, P<0.001) were risk factors of anxiety. Conclusions Patients with DR who underwent vitrectomy and silicone oil filling are more prone to have pain and anxiety than those with simple vitrectomy. Evaluating psychological status of patients with diabetic retinopathy is significant to improve patient compliance as well as prevent and control complications.
An epidemiological survey and risk factors analysis of chronic obstructive pulmonary disease in Hubei Province
TANG Yu-meng, LI Qian, ZHANG Lan, LIU Xin-nian, LI Quan, PAN Jing-ju, HE Tian-jing, ZHANG Qing-jun
2018, 22(7): 721-725. doi: 10.16462/j.cnki.zhjbkz.2018.07.016
Abstract(524) PDF(49)
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Objective To investigate the prevalence and related influencing factors of chronic obstructive pulmonary disease in four disease surveillance points of Hubei Province. Methods A total of 2 400 residents aged over 40 years were surveyed through multistage clustering sampling method by questionnaire, body measurement, and pulmonary function test. Based on the complex sampling design, χ2 test and unconditional multivariate logistics regression analysis were conducted to identify the influencing factors of COPD. Results A total of 2 389 subjects aged over 40 years were recruited. The number of COPD patients was 213, accounting for 8.92%. The prevalence of COPD was 12.36% (95% CI:6.95%-17.77%). The prevalence of rural areas (13.96%) was higher than urban areas(9.04%), and the prevalence of men (17.47%) was higher than women(6.54%). The χ2 tests showed that the region, gender, age, SBP, BMI, and smoking were COPD-related factors (all P<0.05). The multivariate Logistic regression showed that compared with the age group of 40-49, the age group of 50-(OR=2.316, 95% CI:1.999-2.683), 60-(OR=4.641, 95% CI:2.479-8.687) and over 70 (OR=9.066, 95% CI:5.735-14.333) increased the risk of COPD. Smoking (OR=3.376, 95% CI:2.357-4.834) and using polluting fuels for household heating (OR=1.734, 95% CI:1.264-2.380) were risk factors for COPD. Compared with low body weight, people with overweight (OR=0.599, 95% CI:0.367-0.978) and obesity (OR=0.404, 95% CI:0.218-0.752) had lower risk of getting COPD. Conclusions Men from rural areas in Hubei had relatively high COPD prevalence. People who had elder age, smoking history, and been using polluting fuels for household heating had higher risk of COPD. Targeted intervening measures should be carried out for COPD prevention.
Association between paternal-related factors and childhood acute leukemia based on propensity score matching
GAO Pan, LIANG Ge, WANG Yi-ran, LU Jie
2018, 22(7): 726-730. doi: 10.16462/j.cnki.zhjbkz.2018.07.017
Abstract(396) PDF(23)
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Objective To investigate the association between paternal-related factors and the susceptibility of childhood acute leukemia (AL). Methods Based on case-control study, AL children and their 1:1 controls matched with residential region, age and gender were recruited from four hospitals in Henan Province from 2014 to 2016. Propensity score matching (PSM) was used to equalize covariates, the matching effect was verified by standardized difference method. Conditional Logistic regression was used to analyze the association between variables and childhood AL with the matched data.The adjusted population attributable risk percent (PARP)and subgroup analyses were performed. Results A total of 407 cases and 407 controls were included in the analysis. A total 270 pairs of cases and controls were matched by PSM. The standardized difference values of 16 covariates were less than 0.1 after PSM. Conditional Logistic regression showed that paternal exposure to pesticides (ORadj=1.93, 95% CI:1.23-3.05), hair coloring (ORadj=2.31, 95% CI:1.04-5.12) 6 months before pregnancy increased the risk of childhood AL, of which PARP were 11.42%, 4.62% respectively. The relationship between paternal exposure to pesticides and childhood AL were still obvious in sub-population with male, age at diagnosis less than 5 years old, rural residents, and those with paternal exposure to tobacco (all P<0.05). Conclusion Paternal exposure to pesticides, hair coloring 6 months before pregnancy can increase the susceptibility of childhood AL, which should be controlled in prenatal care.
Effect of costimulatory molecules B7-H4 on T lymphocyte subsets of NOD mice in SjÖgren's syndrome
WANG Qi-kai, YUAN Xiang, ZHOU Ying-bo, ZHENG Xu, WANG Xue, LI Xiang-pei, WANG Guo-sheng, WANG Yi-ping, LI Xiao-mei
2018, 22(7): 731-735. doi: 10.16462/j.cnki.zhjbkz.2018.07.018
Abstract(417) PDF(28)
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Objective To investigate the effect of co-stimulatory molecule B7-H4 on the regulation of T cell subsets in (NOD) mice induced by SjÖgren's syndrome (SS). Methods Female NOD mice were randomly divided into baseline group, normal saline (NS) group, B7-H4-Fc protein group, IgG2a-Fc group. After 0 days and 30 days, The mice were sacrificed after being anesthetized, and the spleen and submandibular glands were taken out. The changes of lymphocyte subsets in spleen single cell suspension were detected by flow cytometry, and the submandibular gland tissue was stained with HE and immunohistochemistry. Results Costimulatory molecule B7-H4 protein was mainly expressed in cytoplasm of submandibular gland ductal endothelial cells in NOD mice. A low expression of B7-H4 protein was found in a large number of lymphocytes infiltrated in the submandibular gland. The degree of inflammatory infiltration of submandibular gland in NOD mice was significantly reduced after intraperitoneal injection of B7-H4-Fc fusion protein at day 30. The percentages of CD4+Foxp3+Tcell/CD4+Tcell in spleen were significantly increased in B7-H4-Fc group compared with IgG2a-Fc group, NS group and baseline group respectively (all P<0.05). The percentage of CD4+IFN-γ+Tcell/CD4+Tcell in B7-H4-Fc group was significantly lower than that in IgG2a-Fc group, NS group and baseline group (all P<0.05). There was no significant difference in the proportion of CD4+IL-17+T cells in the spleen between the three groups in the proportion of CD4+T cells. Conclusions B7-H4 protein can delay the infiltration of lymphocyte in the submandibular gland of NOD mice, reduce the level of inflammatory cytokines and inhibit the progress of autoimmune inflammation.
Safety and immunogenicity of a domestic recombinant hepatitis E vaccine in a 16-65 years old population
LIANG Qi, LI Li, SHI Cheng-bo, WANG Wen-juan, LÜ Yun-lei, LU Xiu-fang, MENG Fan-yue, TANG Rong, HU Jia-lei, TAO Hong
2018, 22(7): 736-740. doi: 10.16462/j.cnki.zhjbkz.2018.07.019
Abstract(493) PDF(42)
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Objective To clinically evaluate the safety and immunogenicity of the recombinant hepatitis E vaccine developed by Changchun Biological Products Research Institute Company Limited in a population aged 16 to 65 years old. Methods We first selected subjects who were HEV antibody negative as a target population by screening. Then, a single center, randomized, blind trial with a similar product as a parallel control was conducted that sixty 16-65 years old healthy subjects who were HEV antibody negative were randomized to receive study vaccines or controlled vaccines by the ratio of 1:1. The immunization schedule consisted of 3 doses given on month 0, month 1 and month 6. Adverse reactions/events within 28 days after each dose were recorded. Hepatitis E IgG concentrations were detected with blood samples collected before immunization and 1 month after full schedule. Results We recruited 369 subjects. Among them, 187 were hepatitis E antibody negative after screening, and 60 subjects were enrolled in the trial eventually. Overall incidence of solicited adverse effects after 3 doses vaccination in the test group and the control group were 43.33% and 40.00% respectively. Majority of the adverse effects were mild and moderate. The most common injection-site and systemic reactions were pain and headache. The occurrence rates of adverse effects were not significantly different between groups (all P>0.05). Seropositive rates of HEV antibody after vaccination in the test group and the control group were both 100% and GMCs were 72.53 U/ml and 87.49 U/ml respectively. Conclusion The test vaccine has good safety and immunogenicity and a phase Ⅱ clinical trial can be carried out.
Evaluation and forecast for economic outcomes of hepatitis B immunoprophylaxis strategies in China from 2006 to 2030
ZHANG Shun-xiang, SUN Pan-pan, XIA Yun
2018, 22(7): 741-746. doi: 10.16462/j.cnki.zhjbkz.2018.07.020
Abstract(623) PDF(44)
Abstract:
Objective To evaluate and forecast the economic outcomes of the national hepatitis B immunoprophylaxis strategies from 2006 to 2030, and to promote a nationwide program eliminating hepatitis B launched early in China. Methods The decision analytic-Markov model was used with newborns from 2006 to 2030 as simulation cohort. The cost-effectiveness and cost-benefit analysis were assessed for different scenarios of the last decade and the next fifteen years. The costs and benefits were calculated from the health-care and societal perspectives. The net benefits (NB) and benefit cost ratio (BCR) were considered indicators of cost-benefit analysis. The numbers of hepatitis B virus(HBV)infection and the patients with HBV-related diseases prevented, cumulative quality adjusted life years (QALYs) and the costs per QALYs gained were calculated for cost-effectiveness analysis. Results From 2006 to 2015, the costs of the strategy from two perspectives were RMB 625.664 billion yuan and 812.503 billion yuan, respectively. However, the NB reached up to RMB 4 357.185 billion yuan and 5 370.380 billion yuan, with the BCR of 7.96 and 7.61, respectively. And the costs per QALYs gained were RMB 6 471.53 yuan and 10 023.55 yuan. A total of 96 million QALYs were gained for all birth cohorts. Although the costs with RMB 750.015 billion yuan and 1 029.086 billion yuan will be invested from 2016 to 2030, the more NB with RMB 7 272.935 billion yuan and 8 981.808 billion yuan, the larger BCR with 9.45 and 8.79 and the more QALYs with 137 million will be gained for the strategy implementing sustainably. Also,the RMB 5 398.36 Yuan and 8 389.38 Yuan will be the costs per QALYs gained. Conclusions The national hepatitis B immunoprophylaxis strategies implemented in the last 10 years are with high value of cost-benefit and cost-effectiveness. The strategies will be gained more in the future 15 years, so as to respond the world health organization(WHO)advocacy for eliminating hepatitis B in China.
Current status of drinking water quality for centralized water supply units in China from 2013 to 2016
AI Ping, LI Man, TIAN Yao-hua, HUANG Zhe, CAO Gui-ying, HUANG Chao, YAO Shan-shan, HU Ya-nan, BAO Xiao-yuan, JIN Meng, XU Bei-bei, HU Yong-hua
2018, 22(7): 747-750. doi: 10.16462/j.cnki.zhjbkz.2018.07.021
Abstract(358) PDF(29)
Abstract:
Objective To describe the current status of drinking water quality among centralized water supply units in China, so as to provide evidence for improvement of drinking water condition in China. Methods Data were extracted through the National Health Inspection Information System from 2013 to 2016, China Health Statistics Yearbook and China Statistics Yearbook. Descriptive statistics were conducted to analyze the distributions of unqualified centralized water supply units. χ2 test were performed to determine the statistically significant difference of the unqualified rate. Results During 2013-2016, the annual unqualified rate of centralized water supply units were 1.84%, 2.73%, 2.56% and 2.74% in China, respectively. Unqualified rates for each category of centralized water units showed statistically significant difference (all P<0.001)in 2016. Unqualified rate of public water supply in rural areas (3.85%) was higher compared to urban (1.74%) and self-built facilities (1.33%). Unqualified rate in small and medium-sized (2.40%) water supply units was higher than that in large-sized (0.94%) ones. Areas with high average temperature and annual precipitation had high unqualified rates of centralized water supply units. The unqualified rate was higher in summer (2.06%) and autumn (2.60%). Western regions (4.80%) and southern areas (4.01%) had higher unqualified rate. Conclusion Unqualified rates of centralized water supply units depended largely on seasons and areas. Most unqualified units were small and medium-sized water supply units and located in rural areas.
Research progress of Hantavirus and its interaction with host genes
YANG Qi-song, ZHANG Tian-chen, LIU Xiao-qing, XIE Yun, ZHU Meng-man, HU Guo-liang
2018, 22(7): 751-754. doi: 10.16462/j.cnki.zhjbkz.2018.07.022
Abstract(649) PDF(59)
Abstract:
In recent years, the research on hantavirus gene is getting deeper and deeper with the development of molecular biology and other technologies. A lot of research on different types of hantavirus and rodent hosts, ecological environment and evolution has been carried out at home and abroad. It was found that the prevalence and evolution of hantavirus were closely related to the long-term interaction between hantavirus and hosts.Hantavirus has many genotypes and it is widely distributed all over the world. There were differences in nucleic acid sequence among different serotypes of hantavirus and different hantavirus strains of the same serotype, and the gene fragments of hantavirus of different genotypes were often recombined, which plays an important role in the interaction between hantavirus and host genes. Meanwhile, it is of great significance to the pathogenicity of hantavirus and the clinical diagnosis, treatment and epidemic of the related diseases. Therefore, in this study, the current epidemic status, biological characteristics and interaction with host genes of hantavirus were reviewed.
Application of GM(1,1) model in predicting the incidence of maternal mortality rate
WANG Ya-wen, SHEN Zhong-zhou, MA Shuai, JIANG Yu
2018, 22(7): 755-757. doi: 10.16462/j.cnki.zhjbkz.2018.07.023
Abstract(404) PDF(355)
Abstract:
Risk factors for the development of distant metastasis in colorectal cancer patients after curative resection
PENG Hao, HE Lei, TAO Ying-tian, YU Chao, YANG Yang
2018, 22(7): 758-760. doi: 10.16462/j.cnki.zhjbkz.2018.07.024
Abstract(537) PDF(41)
Abstract:
The Pioneer of Multivariate Statistics: George Udny Yule
ZHANG Yu-yang, CHENG Zi-mei, WU Jun, YE Dong-qing
2018, 22(7): 761-763. doi: 10.16462/j.cnki.zhjbkz.2018.07.025
Abstract(583) PDF(34)
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George Udny Yule (1871-1951) is one of the greatest statisticians from the late 19th century to the middle of 20th century. He pioneered a multiple regression and correlation analysis method and was the founder of modem time series analysis. He respected science, attached importance to the combination of theory and practice, realized the leap from statistics to biology in statistics, and extended statistics to other areas such as biology, sociology, and economics, and promoted the historical progress of statistics.

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